多功能含氟砌块：-CF=1,3-烯炔。
Versatile Fluorine-Containing Building Blocks: -CF-1,3-enynes.
机构信息
Department of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China.
出版信息
Molecules. 2022 Dec 17;27(24):9020. doi: 10.3390/molecules27249020.
Abstract
The development of diversity-oriented synthesis based on fluorine-containing building blocks has been one of the hot research fields in fluorine chemistry. -CF-1,3-enynes, as one type of fluorine-containing building blocks, have attracted more attention in the last few years due to their distinct reactivity. Numerous value-added trifluoromethylated or non-fluorinated compounds which have biologically relevant structural motifs, such as -, -, and -heterocycles, carboncycles, fused polycycles, and multifunctionalized allenes were synthesized from these fluorine-containing building blocks. This review summarizes the most significant developments in the area of synthesis of organofluorine compounds based on -CF-1,3-enynes, providing a detailed overview of the current state of the art.
摘要
基于含氟砌块的多样性导向合成的发展一直是氟化学的热门研究领域之一。-CF-1,3-烯炔作为一种含氟砌块，由于其独特的反应性，在过去几年中引起了更多的关注。大量具有生物相关结构模体的增值三氟甲基化或非氟化化合物，如 -、-和 -杂环、碳环、稠合多环和多功能化的丙二烯，都可以从这些含氟砌块中合成得到。本文综述了基于-CF-1,3-烯炔的有机氟化合物合成领域的最新进展，详细介绍了该领域的最新技术水平。
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