The Key Laboratory of Modern Toxicology, Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 210029, China.
Safety Assessment and Research Center for Drug, Pesticide and Veterinary Drug of Jiangsu Province, Nanjing Medical University, Nanjing 210029, China.
Nutrients. 2022 Dec 8;14(24):5235. doi: 10.3390/nu14245235.
Magnesium is one of the most abundant essential minerals in the body. Magnesium supplements mostly have low bioavailability, except magnesium L-threonate. In 2010, a novel magnesium compound, magnesium L-threonate (Magtein) was identified and was shown to raise the magnesium levels in the brain and neurons effectively. In this double-blind, placebo-controlled study, MagteinPS, a magnesium L-threonate (Magtein)- and phosphatidylserine-based formulation additionally containing vitamins C and D, was tested for its cognitive benefits in 109 healthy Chinese adults aged 18-65 years. Subjects were randomly assigned to receive either MagteinPS or placebo (starch) capsules, at a dose of 2 g/day. "The Clinical Memory Test", the standard test commonly used in Chinese hospitals and academic institutes for cognitive evaluation, was administered before and 30 days after subjects received the supplement. Subjects receiving MagteinPS showed significant improvements over the control group in all five subcategories of "The Clinical Memory Test" as well as the overall memory quotient scores. The older participants showed more improvement than younger participants. Results indicated significant benefits of MagteinPS in improving memory and cognition in healthy Chinese adults.
镁是体内含量最丰富的必需矿物质之一。除了 L-苏糖酸镁以外，镁补充剂的生物利用度大多较低。2010 年，一种新型镁化合物，L-苏糖酸镁（Magtein）被发现，能够有效地提高大脑和神经元中的镁水平。在这项双盲、安慰剂对照研究中，MagteinPS，一种含有 L-苏糖酸镁（Magtein）和磷脂酰丝氨酸的配方，另外还含有维生素 C 和 D，在 109 名年龄在 18-65 岁的健康中国成年人中进行了认知益处测试。受试者被随机分配接受 MagteinPS 或安慰剂（淀粉）胶囊，剂量为每天 2 克。“临床记忆测试”是中国医院和学术机构常用的认知评估标准测试，在受试者接受补充剂之前和 30 天后进行。与对照组相比，接受 MagteinPS 的受试者在“临床记忆测试”的所有五个子类别以及整体记忆商数评分上均有显著改善。年龄较大的参与者比年龄较小的参与者改善更明显。结果表明 MagteinPS 对改善健康中国成年人的记忆和认知能力有显著益处。
