Cepeda Violeta, Ródenas-Munar Marina, García Silvia, Bouzas Cristina, Tur Josep A
Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, Guillem Colom Bldg, Campus, E-07122 Palma de Mallorca, Spain.
Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain.
Antioxidants (Basel). 2025 Jun 16;14(6):740. doi: 10.3390/antiox14060740.
Magnesium plays a crucial role in over 300 enzymatic reactions related to energy production, muscle contraction, and nerve function. Given its essential biological functions and increasing prevalence of suboptimal intake, magnesium supplementation has gained attention for its potential health benefits, particularly in mitigating oxidative stress and inflammation. This systematic review and meta-analysis aimed to evaluate the antioxidant effects of dietary and supplemental magnesium on several biomarkers related to oxidative stress and inflammation. A systematic search of studies published from 2000 to 2025 identified 28 relevant articles, including both animal and human studies. The meta-analysis assessed the effects of magnesium supplementation on oxidative stress biomarkers such as nitric oxide (NO), total antioxidant capacity (TAC), malondialdehyde (MDA), glutathione (GSH), and C-reactive protein (CRP). While results showed a statistically significant reduction in CRP levels, suggesting an anti-inflammatory effect, no conclusive impact on oxidative stress biomarkers was observed. The findings highlight magnesium's potential role in inflammation regulation, though its direct antioxidant effects remain uncertain. Further high-quality clinical trials are needed to clarify the impact of magnesium supplementation on oxidative stress and to explore its broader health implications.
镁在与能量产生、肌肉收缩和神经功能相关的300多种酶促反应中起着至关重要的作用。鉴于其重要的生物学功能以及摄入不足的情况日益普遍，镁补充剂因其潜在的健康益处而受到关注，尤其是在减轻氧化应激和炎症方面。本系统评价和荟萃分析旨在评估膳食镁和补充镁对几种与氧化应激和炎症相关的生物标志物的抗氧化作用。对2000年至2025年发表的研究进行系统检索，确定了28篇相关文章，包括动物研究和人体研究。荟萃分析评估了补充镁对氧化应激生物标志物的影响，如一氧化氮（NO）、总抗氧化能力（TAC）、丙二醛（MDA）、谷胱甘肽（GSH）和C反应蛋白（CRP）。虽然结果显示CRP水平有统计学意义的降低，表明具有抗炎作用，但未观察到对氧化应激生物标志物有确凿影响。研究结果突出了镁在炎症调节中的潜在作用，但其直接的抗氧化作用仍不确定。需要进一步的高质量临床试验来阐明补充镁对氧化应激的影响，并探索其更广泛的健康意义。
