Cardiovascular Department, First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an 710061, China.
Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an 710061, China.
Nutrients. 2022 Dec 16;14(24):5344. doi: 10.3390/nu14245344.
Life's Simple 7 (LS7) is the American Heart Association's (AHA) proposal for a healthy lifestyle, also known as cardiovascular health (CVH) metrics. However, the association between CVH metrics and the severity of hepatic steatosis and liver fibrosis detected by transient elastography is unknown. We performed a cross-sectional study using the data from the 2017-2018 National Health and Nutrition Examination Survey (NHANES) cycle. The controlled attenuation parameter (CAP) and liver stiffness measurement (LSM) were used to evaluate the severity of hepatic steatosis and liver fibrosis and to define NAFLD, advanced liver fibrosis, and cirrhosis. A total of 2679 participants were included. Multivariate linear regression analysis revealed that per 1-unit increase in the CVH metric, CAP and LSM decreased by 8.565 units and 0.274 units, respectively. In the multivariate logistic regression analysis, the risk of NAFLD, advanced liver fibrosis, and cirrhosis were 7, 10, and 6 times higher in the poor CVH group than in the ideal CVH group. Subgroup analysis indicated that CVD patients and non-Hispanic whites could benefit more from ideal CVH. In conclusion, adherence to ideal CVH metrics, as proposed by the AHA, can significantly reduce the risk of hepatic steatosis and liver fibrosis.
LS7 是美国心脏协会(AHA)提出的一种健康生活方式,也称为心血管健康(CVH)指标。然而,CVH 指标与通过瞬时弹性成像检测到的肝脂肪变性和肝纤维化严重程度之间的关系尚不清楚。我们使用 2017-2018 年全国健康和营养检查调查(NHANES)周期的数据进行了一项横断面研究。受控衰减参数(CAP)和肝脏硬度测量(LSM)用于评估肝脂肪变性和肝纤维化的严重程度,并定义非酒精性脂肪性肝病(NAFLD)、晚期肝纤维化和肝硬化。共纳入 2679 名参与者。多变量线性回归分析显示,CVH 指标每增加 1 个单位,CAP 和 LSM 分别降低 8.565 个单位和 0.274 个单位。在多变量逻辑回归分析中,不良 CVH 组发生 NAFLD、晚期肝纤维化和肝硬化的风险分别是非理想 CVH 组的 7 倍、10 倍和 6 倍。亚组分析表明,CVD 患者和非西班牙裔白人可能从理想的 CVH 中获益更多。总之,遵循 AHA 提出的理想 CVH 指标可以显著降低肝脂肪变性和肝纤维化的风险。
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