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从越南采集的植物叶和嫩枝中分离出的具有抗糖尿病活性的成分。

Components with Anti-Diabetic Activity Isolated from the Leaves and Twigs of Collected in Vietnam.

作者信息

Nguyen Minh Tuyet Thi, Hsu I-Chi, Liu Hui-Kang, Lin Yu-Chi, Chen Shu-Rong, Chang Fang-Rong, Cheng Yuan-Bin

机构信息

Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.

Division of Pharmacy, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung 813204, Taiwan.

出版信息

Pharmaceuticals (Basel). 2022 Dec 12;15(12):1543. doi: 10.3390/ph15121543.

DOI:10.3390/ph15121543
PMID:36558993
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9785221/
Abstract

A phytochemical investigation of the leaves and twigs of (Rutaceae), collected in Vietnam, yielded three new compounds named glyfuran (), glyphyllamide (), and glyphyllazole (), along with twenty-five known compounds (-). The structures of isolates were determined by IR, MS, NMR, and UV data analyses. In the anti-diabetic activity screening, (+)-isoaltholacton (), glycoborinine (), 2',4'-dihydroxy-4,6'-dimethoxychalcone (), and flavokawain A () simultaneously exhibited inhibition of dipeptidyl peptidase-4 (DPP4) and stimulation of the glucagon-like peptide-1 (GLP-1) secretion on the murine intestinal secretin tumor cell line (STC-1).

摘要

对采自越南的芸香科（Rutaceae）某植物的叶和嫩枝进行植物化学研究，得到了三种新化合物，分别命名为glyfuran（）、glyphyllamide（）和glyphyllazole（），以及25种已知化合物（ - ）。通过红外光谱（IR）、质谱（MS）、核磁共振（NMR）和紫外光谱（UV）数据分析确定了分离物的结构。在抗糖尿病活性筛选中，（+） - 异欧前胡内酯（）、甘草硼宁（）、2'，4'-二羟基 - 4，6'-二甲氧基查耳酮（）和黄樟素A（）在小鼠肠促胰液素肿瘤细胞系（STC-1）上同时表现出对二肽基肽酶 - 4（DPP4）的抑制作用和对胰高血糖素样肽 - 1（GLP-1）分泌的刺激作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab2d/9785221/f9bed62c4f0f/pharmaceuticals-15-01543-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab2d/9785221/56d48495cfe0/pharmaceuticals-15-01543-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab2d/9785221/781fa5dea406/pharmaceuticals-15-01543-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab2d/9785221/e0a3e5ee5136/pharmaceuticals-15-01543-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab2d/9785221/f9bed62c4f0f/pharmaceuticals-15-01543-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab2d/9785221/56d48495cfe0/pharmaceuticals-15-01543-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab2d/9785221/781fa5dea406/pharmaceuticals-15-01543-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab2d/9785221/e0a3e5ee5136/pharmaceuticals-15-01543-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab2d/9785221/f9bed62c4f0f/pharmaceuticals-15-01543-g004.jpg

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