Components with Anti-Diabetic Activity Isolated from the Leaves and Twigs of Collected in Vietnam.

A phytochemical investigation of the leaves and twigs of (Rutaceae), collected in Vietnam, yielded three new compounds named glyfuran (), glyphyllamide (), and glyphyllazole (), along with twenty-five known compounds (-). The structures of isolates were determined by IR, MS, NMR, and UV data analyses. In the anti-diabetic activity screening, (+)-isoaltholacton (), glycoborinine (), 2',4'-dihydroxy-4,6'-dimethoxychalcone (), and flavokawain A () simultaneously exhibited inhibition of dipeptidyl peptidase-4 (DPP4) and stimulation of the glucagon-like peptide-1 (GLP-1) secretion on the murine intestinal secretin tumor cell line (STC-1).