Melikoglu Mehmet, Pala Erdal, Bayraktar Mustafa
Department of Skin and Venereal Diseases, Faculty of Medicine, University of Atatürk, Erzurum, Turkey.
Department of Skin and Venereal Diseases, Faculty of Medicine, University of Atatürk, Erzurum, Turkey;
Allergol Immunopathol (Madr). 2022 Dec 21;50(S Pt 2):15-23. doi: 10.15586/aei.v50iSP2.784. eCollection 2022.
Acute urticaria and angioedema are emergency dermatological conditions associated with various etiologic factors.
To determine the etiological causes in patients with acute urticaria and angioedema, and to investigate whether more than one etiological cause was present, along with the patients' laboratory values.
The study was conducted in a tertiary hospital with one center. Etiological causes and laboratory parameters in 284 patients diagnosed with acute urticaria and angioedema were retrospectively studied.
A total of 284 patients were included in the study. The mean age of the patients was 42.7 ± 15.6 years, where 163 (57.4%) were women and 121 (42.6%) were men. Acute urticaria and angioedema occurred together in 149 (52.5%) patients. At least one precipitating factor among the predisposing risk factors was present in 220 (77.5%) patients, and more than one precipitating factor was found in 51 (18%) patients. Medication use was found in 157 (55.3%) patients and infection in 54 (19%). The development of urticaria after food consumption was noted in nine (3.2%) individuals. A history of infection and medication intake was present in 50 (17.6%) patients. A joint history of food consumption and medication intake was present in only one patient. Elevated C-reactive protein level was found in 178 (62.7%) patients and elevated anti-streptolysin O titer in 41 (14.4%) patients. Vitamin B12 deficiency was found in 116 (40.8%) patients and vitamin D deficiency in 254 (89.4%).
Acute urticaria and angioedema may occur as a result of multiple etiological factors, in which different triggers may be present simultaneously.
急性荨麻疹和血管性水肿是与多种病因相关的皮肤科急症。
确定急性荨麻疹和血管性水肿患者的病因，并调查是否存在不止一种病因，以及患者的实验室检查值情况。
本研究在一家拥有一个中心的三级医院进行。对284例诊断为急性荨麻疹和血管性水肿的患者的病因及实验室参数进行回顾性研究。
本研究共纳入284例患者。患者的平均年龄为42.7±15.6岁，其中163例（57.4%）为女性，121例（42.6%）为男性。149例（52.5%）患者同时出现急性荨麻疹和血管性水肿。在220例（77.5%）患者的诱发危险因素中至少存在一种促发因素，51例（18%）患者发现不止一种促发因素。157例（55.3%）患者发现有用药史，54例（19%）患者有感染史。9例（3.2%）个体在食用食物后出现荨麻疹。50例（17.6%）患者有感染和用药史。仅1例患者有食物摄入和用药史。178例（62.7%）患者C反应蛋白水平升高，41例（14.4%）患者抗链球菌溶血素O滴度升高。116例（40.8%）患者存在维生素B12缺乏，254例（89.4%）患者存在维生素D缺乏。
急性荨麻疹和血管性水肿可能由多种病因引起，其中不同的触发因素可能同时存在。
