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具有粘性、抗菌性且双交联的羧化聚乙烯醇/壳聚糖水凝胶,可促进动态皮肤伤口愈合。

Adhesive, antibacterial and double crosslinked carboxylated polyvinyl alcohol/chitosan hydrogel to enhance dynamic skin wound healing.

作者信息

Liu Sudan, Li Diansen, Wang Yu, Zhou Guoqiang, Ge Kun, Jiang Lei

机构信息

Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology, Ministry of Education, School of Chemistry, Beihang University, Beijing 100191, China.

Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology, Ministry of Education, School of Chemistry, Beihang University, Beijing 100191, China; Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing 100191, China.

出版信息

Int J Biol Macromol. 2023 Feb 15;228:744-753. doi: 10.1016/j.ijbiomac.2022.12.169. Epub 2022 Dec 20.

Abstract

An available dressing material which promotes skin tissue repair is of significant importance for public health. Moreover, dynamic wounds have special requirements for hydrogel dressings due to their motion state. Correspondingly, a double crosslinked hydrogel was prepared based on amide and coordination bonds from carboxylated polyvinyl alcohol (PC) and chitosan (CS)/Fe. The hydrogel exhibited excellent swelling ratio and suitable biodegradability, which is beneficial to the tissue repair. The results showed that hydrogels with crosslinked structure possessed better unique properties, such as stronger mechanical (78 kPa of G') and adhesion properties, and shorter self-healing time (5 mins), the change of which was consistent with dynamic wounds. The hydrogel exhibited not only antibacterial activity (98 % fatality rate), but also superior hemostatic capacity during the wound healing process. In addition, the hydrogel could shorten skin healing time to 14 days, and obviously accelerated skin structure reconstruction by promoting angiogenesis and collagen deposition. Therefore, double crosslinked hydrogel is a promising dynamic wound dressing.

摘要

一种能够促进皮肤组织修复的现有敷料材料对公众健康具有重要意义。此外,由于动态伤口的运动状态,其对水凝胶敷料有特殊要求。相应地,基于羧化聚乙烯醇(PC)和壳聚糖(CS)/铁通过酰胺键和配位键制备了一种双交联水凝胶。该水凝胶表现出优异的溶胀率和合适的生物降解性,这有利于组织修复。结果表明,具有交联结构的水凝胶具有更好的独特性能,如更强的力学性能(储能模量G'为78 kPa)和粘附性能,以及更短的自愈时间(5分钟),其变化与动态伤口一致。该水凝胶在伤口愈合过程中不仅表现出抗菌活性(致死率98%),还具有优异的止血能力。此外,该水凝胶可将皮肤愈合时间缩短至14天,并通过促进血管生成和胶原蛋白沉积明显加速皮肤结构重建。因此,双交联水凝胶是一种很有前景的动态伤口敷料。

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