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水凝胶与伤口愈合:现状与未来展望

Hydrogels and Wound Healing: Current and Future Prospects.

作者信息

Gounden Varshan, Singh Moganavelli

机构信息

Nano-Gene and Drug Delivery Laboratory, Discipline of Biochemistry, University of KwaZulu-Natal, Private Bag X54001, Durban 4000, South Africa.

出版信息

Gels. 2024 Jan 5;10(1):43. doi: 10.3390/gels10010043.

Abstract

The care and rehabilitation of acute and chronic wounds have a significant social and economic impact on patients and global health. This burden is primarily due to the adverse effects of infections, prolonged recovery, and the associated treatment costs. Chronic wounds can be treated with a variety of approaches, which include surgery, negative pressure wound therapy, wound dressings, and hyperbaric oxygen therapy. However, each of these strategies has an array of limitations. The existing dry wound dressings lack functionality in promoting wound healing and exacerbating pain by adhering to the wound. Hydrogels, which are commonly polymer-based and swell in water, have been proposed as potential remedies due to their ability to provide a moist environment that facilitates wound healing. Their unique composition enables them to absorb wound exudates, exhibit shape adaptability, and be modified to incorporate active compounds such as growth factors and antibacterial compounds. This review provides an updated discussion of the leading natural and synthetic hydrogels utilized in wound healing, details the latest advancements in hydrogel technology, and explores alternate approaches in this field. Search engines Scopus, PubMed, Science Direct, and Web of Science were utilized to review the advances in hydrogel applications over the last fifteen years.

摘要

急慢性伤口的护理与康复对患者及全球健康有着重大的社会和经济影响。这种负担主要源于感染的不良影响、恢复时间延长以及相关的治疗费用。慢性伤口可用多种方法治疗,包括手术、负压伤口治疗、伤口敷料和高压氧治疗。然而,这些策略中的每一种都有一系列局限性。现有的干性伤口敷料在促进伤口愈合方面缺乏功能性,并且会因粘附伤口而加剧疼痛。水凝胶通常基于聚合物,在水中会膨胀,由于其能够提供促进伤口愈合的湿润环境,已被提议作为潜在的治疗方法。其独特的成分使其能够吸收伤口渗出液,具有形状适应性,并可进行改性以加入生长因子和抗菌化合物等活性化合物。本综述对伤口愈合中使用的主要天然和合成水凝胶进行了更新的讨论,详述了水凝胶技术的最新进展,并探索了该领域的替代方法。利用搜索引擎Scopus、PubMed、Science Direct和Web of Science回顾了过去十五年中水凝胶应用的进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9188/10815795/e7d4cdbd09a7/gels-10-00043-g001.jpg

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