Lam S K, Lam K C, Lai C L, Yeung C K, Yam L Y, Wong W S
Gastroenterology. 1979 Feb;76(2):315-22.
The effect of aluminum-magnesium hydroxide tablets (800 mg seven times per day) and that of sulpiride, a hypothalamic neurolaptic, were studied in 101 patients with duodenal ulcer in a double-blind controlled 4-wk trial. Significantly more of the patients treated with antacid, sulpiride, or antacid-sulpiride combination showed a greater than 50% reduction in ulcer size than did the patients treated with placebo. However, only in the antacid- and antacid-sulpiride-treated groups did the ulcer, with and without residual inflammation, disappear statistically more often than in the placebo-treated group. Furthermore, only in the antacid-sulpiride-treated group did complete healing, with no trace of inflammation, occur statistically more often than in the placebo-treated group. Disappearance of ulcer pain was likewise statistically more frequent in the antacid-sulpiride group than in the placebo-treated group. Antacid therapy with aluminum-magnesium hydroxide tablets appears to accelerate the rate of ulcer healing. Sulpiride appears to have a minor but definite synergism with antacids. Cigarette smoking affected ulcer healing adversely; on the other hand, factors favorable to healing were the early onset age of ulcer symptoms and acid hypersecretion. Male patients also healed more favorably than females.
在一项为期4周的双盲对照试验中，对101例十二指肠溃疡患者研究了氢氧化铝镁片（每日7次，每次800毫克）以及下丘脑神经安定药舒必利的疗效。与接受安慰剂治疗的患者相比，接受抗酸剂、舒必利或抗酸剂 - 舒必利联合治疗的患者中，溃疡面积缩小超过50%的比例显著更高。然而，仅在抗酸剂治疗组和抗酸剂 - 舒必利治疗组中，无论有无残留炎症的溃疡，在统计学上比安慰剂治疗组更常消失。此外，仅在抗酸剂 - 舒必利治疗组中，完全愈合且无炎症痕迹的情况在统计学上比安慰剂治疗组更常出现。抗酸剂 - 舒必利组溃疡疼痛消失在统计学上也比安慰剂治疗组更频繁。用氢氧化铝镁片进行抗酸治疗似乎能加速溃疡愈合速度。舒必利似乎与抗酸剂有轻微但明确的协同作用。吸烟对溃疡愈合有不利影响；另一方面，有利于愈合的因素是溃疡症状的早期发病年龄和胃酸分泌过多。男性患者的愈合情况也比女性更有利。
