Korman M G, Shaw R G, Hansky J, Schmidt G T, Stern A I
Gastroenterology. 1981 Jun;80(6):1451-3.
Fifty consecutive patients with symptomatic endoscopically proven duodenal ulcer were randomized double-blind to Mylanta II or cimetidine treatment schedules. Smoking habits were noted, but patients were not advised to alter these. Healing was determined by reendoscopy at 6 wk. Eighty percent of patients on active cimetidine and 52% on active Mylanta II had healed at 6 wk (not significantly); 85% of nonsmokers healed compared to 44% of smokers (p less than 0.03). In smokers, cimetidine achieved healing in 50%, Mylanta II in 39% (not significantly); while in nonsmokers, cimetidine achieved healing in 100%, Mylanta II in 67% (not significantly). These results indicate a significant and equally adverse effect of smoking on the healing rate of duodenal ulcer achieved by either cimetidine or Mylanta II.
连续50例经内镜检查证实有症状的十二指肠溃疡患者被随机双盲分为服用胃得乐II或西咪替丁治疗组。记录吸烟习惯，但未建议患者改变这些习惯。6周时通过再次内镜检查确定愈合情况。服用活性西咪替丁的患者中有80%在6周时愈合，服用活性胃得乐II的患者中有52%愈合（无显著差异）；不吸烟者中有85%愈合，吸烟者中有44%愈合（p<0.03）。在吸烟者中，西咪替丁的愈合率为50%，胃得乐II为39%（无显著差异）；而在不吸烟者中，西咪替丁的愈合率为100%，胃得乐II为67%（无显著差异）。这些结果表明，吸烟对西咪替丁或胃得乐II治疗十二指肠溃疡的愈合率有显著且同等的不利影响。
