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病例报告：通过宏基因组下一代测序和全基因组测序诊断的免疫功能正常患者的感染。

Case report: infection in an immunocompetent patient diagnosed by metagenomic next-generation sequencing and whole genome sequencing.

机构信息

The First Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, China.

The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.

出版信息

Front Immunol. 2022 Dec 9;13:1053914. doi: 10.3389/fimmu.2022.1053914. eCollection 2022.

DOI:10.3389/fimmu.2022.1053914
PMID:36569853
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9780257/
Abstract

The infection of is a relatively uncommon form of pulmonary nocardiosis seen in clinical patients. In general, nocardiosis tends to occur in patients with immune deficiency. Here, we report a 23-year-old female who was admitted to the hospital due to cough and sputum production over 10 years, diagnosed with bronchiectasis. The infection was identified by metagenomic next-generation sequencing and whole genome sequencing. Imipenem/cilastatin and compound sulfamethoxazole tablets were used to control the infection and the pulmonary inflammation subsided gradually.

摘要

感染是临床患者中相对少见的肺部奴卡菌病形式。一般来说，奴卡菌病倾向于发生在免疫功能低下的患者中。在此，我们报告了一例 23 岁女性，因咳嗽、咳痰 10 余年就诊，诊断为支气管扩张症。通过宏基因组二代测序和全基因组测序鉴定为奴卡菌感染。使用亚胺培南/西司他丁和复方磺胺甲噁唑片控制感染，肺部炎症逐渐消退。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2992/9780257/bdbc365b8c6b/fimmu-13-1053914-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2992/9780257/95a09698e618/fimmu-13-1053914-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2992/9780257/5511b03ea66a/fimmu-13-1053914-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2992/9780257/96c5e15f3bba/fimmu-13-1053914-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2992/9780257/f42bb465de55/fimmu-13-1053914-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2992/9780257/bdbc365b8c6b/fimmu-13-1053914-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2992/9780257/95a09698e618/fimmu-13-1053914-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2992/9780257/5511b03ea66a/fimmu-13-1053914-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2992/9780257/96c5e15f3bba/fimmu-13-1053914-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2992/9780257/f42bb465de55/fimmu-13-1053914-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2992/9780257/bdbc365b8c6b/fimmu-13-1053914-g005.jpg

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