Hatami Hamed, Sajedi Atefe, Mir Seyed Mostafa, Memar Mohammad Yousef
Department of Immunology, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran.
Metabolic Disorders Research Center Golestan University of Medical Sciences Gorgan Iran.
Health Sci Rep. 2022 Dec 21;6(1):e996. doi: 10.1002/hsr2.996. eCollection 2023 Jan.
In most regions, cancer ranks the second most frequent cause of death following cardiovascular disorders.
In this article, we review the various aspects of glycolysis with a focus on types of MCTs and the importance of lactate in cancer cells.
Metabolic changes are one of the first and most important alterations in cancer cells. Cancer cells use different pathways to survive, energy generation, growth, and proliferation compared to normal cells. The increase in glycolysis, which produces substances such as lactate and pyruvate, has an important role in metastases and invasion of cancer cells. Two important cellular proteins that play a role in the production and transport of lactate include lactate dehydrogenase and monocarboxylate transporters (MCTs). These molecules by their various isoforms and different tissue distribution help to escape the immune system and expansion of cancer cells under different conditions.
在大多数地区，癌症是仅次于心血管疾病的第二大常见死因。
在本文中，我们综述糖酵解的各个方面，重点关注单羧酸转运蛋白（MCTs）的类型以及乳酸在癌细胞中的重要性。
代谢变化是癌细胞最早且最重要的改变之一。与正常细胞相比，癌细胞利用不同途径来生存、产生能量、生长和增殖。糖酵解增加会产生乳酸和丙酮酸等物质，在癌细胞的转移和侵袭中起重要作用。在乳酸生成和转运过程中发挥作用的两种重要细胞蛋白包括乳酸脱氢酶和单羧酸转运蛋白（MCTs）。这些分子通过其各种同工型和不同的组织分布，有助于在不同条件下逃避免疫系统并促进癌细胞的扩散。
