食管鳞癌中的 microRNAs：在预后、诊断和药物递送中的应用。
MicroRNAs in esophageal squamous cell carcinoma: Application in prognosis, diagnosis, and drug delivery.
机构信息
Department of Nutrition, Khalkhal University of Medical Sciences, Khalkhal, Iran.
Department of Clinical Biochemistry, School of Medicine, Tarbiat Modares University, Tehran, Iran.
出版信息
Pathol Res Pract. 2022 Dec;240:154196. doi: 10.1016/j.prp.2022.154196. Epub 2022 Nov 2.
MicroRNAs (miRNAs) play a vital role in various cell biology processes, including cancer formation. These small non-coding RNAs could function as diagnostic and prognostic markers. They may involve esophageal squamous cell carcinoma (ESCC) and distinctive miRNA expression profiles; they are also known as therapeutic targets in human diseases. Therefore, in this study, the function of miRNAs was reviewed regarding the prognosis and diagnosis of ESCC. The changes in miRNAs before and after cancer therapy and the effects of miRNAs on chemo-susceptibility patterns were also investigated. MiRNA delivery systems in ESCC were also highlighted, providing a perspective on how these systems can improve miRNA efficiency.
微小 RNA（miRNA）在各种细胞生物学过程中发挥着重要作用，包括癌症的形成。这些小的非编码 RNA 可以作为诊断和预后标志物。它们可能涉及食管鳞状细胞癌（ESCC）和独特的 miRNA 表达谱；它们也是人类疾病的治疗靶点。因此，在这项研究中，我们回顾了 miRNA 在 ESCC 的预后和诊断中的作用。还研究了癌症治疗前后 miRNA 的变化以及 miRNA 对化疗敏感性模式的影响。还强调了 ESCC 中的 miRNA 传递系统，提供了这些系统如何提高 miRNA 效率的视角。
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