Workman-Daniels K L, Hesselbrock V M
Department of Psychiatry, University of Connecticut Health Center, Farmington 06032.
J Stud Alcohol. 1987 May;48(3):187-93. doi: 10.15288/jsa.1987.48.187.
The relationship of childhood hyperkinetic and minimal brain dysfunction (Hk-MBD) to neuropsychological functioning was examined in three groups of young adults. Nonalcoholic offspring of an alcoholic parent (N = 21) and of nonalcoholic parents (N = 21) were examined. A comparison group of similar age alcoholic patients (N = 21) was also studied. Each subject completed a battery of neuropsychological test measures and was administered a checklist on the presence of Hk-MBD symptoms in childhood. Offspring of an alcoholic parent and offspring of nonalcoholic parents could not be distinguished on the basis of their cognitive abilities or their frequency of reported Hk-MBD symptoms in childhood. Alcoholic subjects performed more poorly on measures of verbal and performance intelligence and reported a higher frequency of childhood Hk-MBD symptoms. Further, it was found that the frequency of childhood Hk-MBD symptoms was related to poor performance on certain types of cognitive tasks, regardless of group membership. These findings do not support the suggestion that certain cognitive deficits distinguish persons with a family history for alcoholism. However, poor neuropsychological performance in adulthood, at least on certain types of tasks, appears to be associated with the presence of childhood Hk-MBD.
在三组年轻成年人中研究了儿童多动与轻微脑功能障碍（Hk-MBD）和神经心理功能之间的关系。研究了酗酒父母的非酗酒后代（N = 21）和非酗酒父母的非酗酒后代（N = 21）。还研究了一组年龄相仿的酗酒患者作为对照组（N = 21）。每个受试者完成了一系列神经心理测试，并填写了一份关于童年时期是否存在Hk-MBD症状的清单。酗酒父母的后代和非酗酒父母的后代在认知能力或童年时期报告的Hk-MBD症状频率方面无法区分。酗酒受试者在言语和操作智力测试中的表现更差，并且报告的童年Hk-MBD症状频率更高。此外，发现童年Hk-MBD症状的频率与某些类型认知任务的表现不佳有关，无论所属组别如何。这些发现不支持某些认知缺陷可区分有酗酒家族史的人的观点。然而，成年期神经心理表现不佳，至少在某些类型的任务上，似乎与童年时期存在Hk-MBD有关。
