危重新生儿肺动脉瓣狭窄患者左心室功能障碍：超声心动图预测因素。一项单中心回顾性研究。
Left ventricle dysfunction in patients with critical neonatal pulmonary stenosis: echocardiographic predictors. A single-center retrospective study.
机构信息
Department of Cardiac Surgery, Cardiology and Heart and Lung Transplant, Pediatric Hospital Bambino Gesù, Roma, Roma, Italy.
Mediterranean Pediatric Cardiology Center "Pediatric Hospital Bambino Gesù", San Vincenzo Hospital, Taormina, Italy.
出版信息
PeerJ. 2022 Dec 21;10:e14056. doi: 10.7717/peerj.14056. eCollection 2022.
BACKGROUND
The aim of this study is to identify echocardiographic predictors of transient left ventricle dysfunction after pulmonary valve balloon dilatation (PVBD), in neonates with pulmonary valve stenosis (PVS) and atresia with intact septum (PAIVS) at birth.
METHODS
The study includes patients admitted at the Bambino Gesù Children Hospital from January 2012 to January 2017. Clinical, echocardiographic and cardiac catheterization data before and after PVBD were retrospectively analyzed.
RESULTS
Twenty-nine infants were included in the study (21 male and eight female). The median age was 5.8 ± 7.1 days. Eight patients developed transient LV dysfunction (three PAIVS and five PVS) and comparing data before and after the procedure, there was no difference in right ventricle geometrical and functional parameters except for evidence of at least moderate pulmonary valve regurgitation after PVBD.
CONCLUSION
Moderate to severe degree pulmonary valve regurgitation was significant associated to LV dysfunction ( < 0.05) in PVS and PAIVS patients.
背景
本研究旨在确定出生时患有肺动脉瓣狭窄（PVS）伴完整间隔的肺动脉瓣闭锁（PAIVS）的新生儿，经肺动脉瓣球囊扩张（PVBD）后短暂左心室功能障碍的超声心动图预测因素。
方法
本研究纳入了 2012 年 1 月至 2017 年 1 月期间在 Bambino Gesù 儿童医院就诊的患者。回顾性分析了 PVBD 前后的临床、超声心动图和心导管检查数据。
结果
本研究共纳入 29 例婴儿（男 21 例，女 8 例）。中位年龄为 5.8 ± 7.1 天。8 例患儿出现短暂左心室功能障碍（3 例 PAIVS 和 5 例 PVS），与术前相比，除 PVBD 后至少中度肺动脉瓣反流外，右心室几何和功能参数无差异。
结论
PVS 和 PAIVS 患者中，中重度肺动脉瓣反流与左心室功能障碍显著相关（<0.05）。
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