Chowdhury Sougata Ghosh, Ray Rachayeeta, Karmakar Parimal
Department of Life Science and Biotechnology, Jadavpur University, Kolkata, 700032, India.
Funct Integr Genomics. 2022 Dec 27;23(1):23. doi: 10.1007/s10142-022-00951-8.
Prostate cancer, one of the major causes of mortality globally is regarded as the second leading cause of mortality among men. It is known to affect the stromal cells surrounding it. Through the use of exosomes, the affected stromal cells can promote the growth and spread of the cancer. Exosomes are known to play a role not only in the development and progression of cancer but also contribute to the drug-resistance character of cancer cells. Recently, the discovery of the small non-coding RNAs or miRNA has attracted attention of cancer researchers as they can regulate the expression of different genes. Therefore, exosomal miRNA can be used as a novel and reliable biomarker for the diagnosis and treatment of prostate cancer. In addition, exosomal miRNAs can also be used as a potential treatment for prostate cancer. The goal of this review is to provide a comprehensive analysis of the current knowledge about the role of exosomal miRNAs in the treatment of patients with prostate cancer and their potential role in monitoring the disease.
前列腺癌是全球主要死因之一，被视为男性第二大死因。已知它会影响其周围的基质细胞。通过外泌体的作用，受影响的基质细胞会促进癌症的生长和扩散。众所周知，外泌体不仅在癌症的发生和发展中起作用，还会导致癌细胞产生耐药性。最近，小型非编码RNA即微小RNA（miRNA）的发现引起了癌症研究人员的关注，因为它们可以调节不同基因的表达。因此，外泌体miRNA可作为一种新型且可靠的生物标志物用于前列腺癌的诊断和治疗。此外，外泌体miRNA也可作为前列腺癌的一种潜在治疗方法。本综述的目的是全面分析目前关于外泌体miRNA在前列腺癌患者治疗中的作用及其在疾病监测中的潜在作用的相关知识。
