Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
School of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
Inflammopharmacology. 2023 Feb;31(1):57-75. doi: 10.1007/s10787-022-01077-w. Epub 2022 Dec 27.
Inflammation plays a critical role in several diseases such as cancer, gastric, heart and nervous system diseases. Data suggest that the activation of mammalian target of rapamycin (mTOR) pathway in epithelial cells leads to inflammation. Statins, the inhibitors of the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA), seem to be able to inhibit the mTOR. Statins are considered to have favorable effects on inflammatory diseases by reducing the complications caused by inflammation and by regulating the inflammatory process and cytokines secretion. This critical review collected data on this topic from clinical, in vivo and in vitro studies published between 1998 and June 2022 in English from databases including PubMed, Google Scholar, Scopus, and Cochrane libraries.
炎症在多种疾病中起着关键作用，如癌症、胃肠道、心脏和神经系统疾病。有数据表明，哺乳动物雷帕霉素靶蛋白（mTOR）途径在上皮细胞中的激活会导致炎症。他汀类药物是 3-羟基-3-甲基戊二酰辅酶 A（HMG-CoA）的抑制剂，似乎能够抑制 mTOR。他汀类药物被认为通过减少炎症引起的并发症，以及通过调节炎症过程和细胞因子的分泌，对炎症性疾病有有利的影响。本综述从 1998 年至 2022 年 6 月，在 PubMed、Google Scholar、Scopus 和 Cochrane 图书馆等英文数据库中，收集了关于该主题的临床、体内和体外研究数据。
