Internal Medicine Department, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.
School of Pharmaceutical Sciences, Capital Medical University, Beijing, China.
Reprod Sci. 2023 Jun;30(6):1952-1964. doi: 10.1007/s43032-022-01156-x. Epub 2022 Dec 27.
Transforming growth factor (TGF)-β1, an angiogenic factor in the maternal circulation, has been suggested to be related to preeclampsia. However, the findings from previous studies were inconsistent. Thus, we conducted a meta-analysis to assess the difference in circulating TGF-β1 levels between women with preeclampsia and normal pregnancies. Twenty-four studies including 1748 women with PE and 1404 women with normal pregnancy were included in our study. The results showed that circulating TGF-β1 levels were not different before the time of active disease (standardized mean differences, - 0.46 [95% CI, - 0.16 to 0.15]; P = 0.000). At the time of active disease, women with preeclampsia (n = 1207) had higher circulating TGF-β1 levels than normotensive controls (n = 912; standardized mean differences, 0.94 [95% CI, 0.52 to 1.35]; P = 0.000). Circulating TGF-β1 levels were higher in both early-onset/severe and late-onset/mild types of preeclampsia. No publication biases were found. We conclude that preeclamptic women have higher circulating TGF-β1 than those with normal pregnancy at the time of preeclampsia diagnosis.
转化生长因子-β1（TGF-β1）是母体循环中的一种血管生成因子，与子痫前期有关。然而，先前的研究结果并不一致。因此，我们进行了一项荟萃分析，以评估子痫前期妇女与正常妊娠妇女循环 TGF-β1 水平的差异。共有 24 项研究纳入了 1748 例子痫前期患者和 1404 例正常妊娠患者。结果表明，在疾病活动前，循环 TGF-β1 水平无差异（标准化均数差，-0.46[95%CI，-0.16 至 0.15]；P=0.000）。在疾病活动时，子痫前期患者（n=1207）的循环 TGF-β1 水平高于正常血压对照组（n=912；标准化均数差，0.94[95%CI，0.52 至 1.35]；P=0.000）。无论是早发型/严重型还是晚发型/轻度型子痫前期患者，其循环 TGF-β1 水平均较高。未发现发表偏倚。我们的结论是，子痫前期患者在子痫前期诊断时的循环 TGF-β1 水平高于正常妊娠妇女。
