Gene polymorphism associated with TGF-β1 and susceptibility to preeclampsia: A meta-analysis and trial sequential analysis.

AIM

Mounts of researches focused on the link between transforming growth factor-beta 1 (TGF-β1) polymorphisms and preeclampsia (PE) which is a hypertensive multisystemic disorder affecting pregnancy. However, the results were inconsistent. Thus, a meta-analysis was performed to obtain more conclusive results.

METHODS

Eligible studies were searched in PubMed, Web of Science, EMBASE, and Scopus. Odds ratios (ORs) with 95% confidence intervals (CIs) were utilized to evaluate the relationship between six TGF-β1 polymorphisms (rs1800468, rs1800469, rs1800470, rs1800471, rs4803455, and rs4803457) and PE susceptibility in five genetic models. The subgroup stratified analysis and trial sequential analysis were performed.

RESULTS

Fourteen studies were included in this meta-analysis with 1941 PE patients and 2488 healthy women. There was no statistically significant association between these six TGF-β1 polymorphisms and PE within five genetic models in the overall population (all p > 0.05). Subgroup stratified analysis revealed there was statistically significant association between TGF-β1 rs1800469 polymorphism and PE within the allele, recessive, and homozygous model in Asian (OR = 1.17, 95% CI = 1.02-1.35; OR = 1.35, 95% CI = 1.06-1.72; OR = 1.48, 95% CI = 1.07-2.05, respectively; all p < 0.05). Trial sequential analysis indicated sufficient proof of such association in the Asian population.

CONCLUSIONS

TGF-β1 rs1800469 is a possible risk factor for PE in Asian populations.