Liu Jing, Song Guang, Zhao Ge, Meng Tao
Department of Obstetrics, The First Affiliated Hospital of China Medical University, Shenyang, China.
Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, China.
J Obstet Gynaecol Res. 2021 Jun;47(6):2031-2041. doi: 10.1111/jog.14751. Epub 2021 Mar 22.
Mounts of researches focused on the link between transforming growth factor-beta 1 (TGF-β1) polymorphisms and preeclampsia (PE) which is a hypertensive multisystemic disorder affecting pregnancy. However, the results were inconsistent. Thus, a meta-analysis was performed to obtain more conclusive results.
Eligible studies were searched in PubMed, Web of Science, EMBASE, and Scopus. Odds ratios (ORs) with 95% confidence intervals (CIs) were utilized to evaluate the relationship between six TGF-β1 polymorphisms (rs1800468, rs1800469, rs1800470, rs1800471, rs4803455, and rs4803457) and PE susceptibility in five genetic models. The subgroup stratified analysis and trial sequential analysis were performed.
Fourteen studies were included in this meta-analysis with 1941 PE patients and 2488 healthy women. There was no statistically significant association between these six TGF-β1 polymorphisms and PE within five genetic models in the overall population (all p > 0.05). Subgroup stratified analysis revealed there was statistically significant association between TGF-β1 rs1800469 polymorphism and PE within the allele, recessive, and homozygous model in Asian (OR = 1.17, 95% CI = 1.02-1.35; OR = 1.35, 95% CI = 1.06-1.72; OR = 1.48, 95% CI = 1.07-2.05, respectively; all p < 0.05). Trial sequential analysis indicated sufficient proof of such association in the Asian population.
TGF-β1 rs1800469 is a possible risk factor for PE in Asian populations.
大量研究聚焦于转化生长因子β1（TGF-β1）基因多态性与先兆子痫（PE）之间的联系，先兆子痫是一种影响妊娠的高血压多系统疾病。然而，结果并不一致。因此，进行了一项荟萃分析以获得更具结论性的结果。
在PubMed、科学网、EMBASE和Scopus中检索符合条件的研究。采用比值比（OR）及95%置信区间（CI）来评估6种TGF-β1基因多态性（rs1800468、rs1800469、rs1800470、rs1800471、rs4803455和rs4803457）与5种遗传模型中PE易感性之间的关系。进行了亚组分层分析和试验序贯分析。
本荟萃分析纳入了14项研究，包括1941例PE患者和2488例健康女性。在总体人群的5种遗传模型中，这6种TGF-β1基因多态性与PE之间均无统计学显著关联（所有p>0.05）。亚组分层分析显示，在亚洲人群中，TGF-β1 rs1800469基因多态性与等位基因、隐性和纯合子模型中的PE之间存在统计学显著关联（OR分别为1.17，95%CI为1.02 - 1.35；OR为1.35，95%CI为1.06 - 1.72；OR为1.48，95%CI为1.07 - 2.05；所有p < 0.05）。试验序贯分析表明在亚洲人群中有足够证据支持这种关联。
TGF-β1 rs1800469是亚洲人群中PE的一个可能危险因素。
