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组胺过敏反应与鲎试剂检测内毒素活性的比较。

Comparison of the histamine hypersensitivity and the Limulus amoebocyte lysate tests for endotoxin activity.

作者信息

Munoz J J, Bergman R K, Robbins K E

出版信息

Infect Immun. 1978 Oct;22(1):292-4. doi: 10.1128/iai.22.1.292-294.1978.

DOI:10.1128/iai.22.1.292-294.1978
PMID:365749
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC422150/
Abstract

The histamine hypersensitivity test and the Limulus amoebocyte lysate test were compared for their effectiveness to quantitate endotoxin activity. The two tests compared favorably in all the trials, except with a sample of endotoxin from Brucella abortus that gave a positive Limulus amoebocyte lysate test at a concentration of 0.001 microgram, while failing to sensitize mice to histamine at a dose of 16 microgram per mouse. The Limulus amoebocyte lysate test was more sensitive than the histamine hypersensitivity test.

摘要

对组胺过敏试验和鲎试剂试验在定量内毒素活性方面的有效性进行了比较。除了一份流产布鲁氏菌内毒素样本外，在所有试验中这两种试验的结果都比较理想。该样本在浓度为0.001微克时鲎试剂试验呈阳性，但以每只小鼠16微克的剂量却未能使小鼠对组胺敏感。鲎试剂试验比组胺过敏试验更敏感。

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Purification and characterization of smooth and rough lipopolysaccharides from Brucella abortus.流产布鲁氏菌光滑型和粗糙型脂多糖的纯化与特性分析
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本文引用的文献

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Some structural and biological properties of Brucella endotoxin.布鲁氏菌内毒素的一些结构和生物学特性。
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ORIGIN AND PROPERTIES OF NATURALLY OCCURRING HAPTEN FROM ESCHERICHIA COLI.来自大肠杆菌的天然存在半抗原的起源与特性
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Pyrogenicity of poly I. poly C in rabbits.聚肌苷酸-聚胞苷酸对家兔的致热原性
Nature. 1969 Aug 16;223(5207):717-8. doi: 10.1038/223717a0.
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A technique for quantitative measurement of endotoxin in human plasma.一种定量测量人血浆中内毒素的技术。
Proc Soc Exp Biol Med. 1971 May;137(1):334-40. doi: 10.3181/00379727-137-35572.
10
Nonspecificity of the limulus amebocyte lysate test: positive reactions with polynucleotides and proteins.鲎试剂检测的非特异性：与多核苷酸和蛋白质的阳性反应。
J Infect Dis. 1973 Sep;128(3):349-52. doi: 10.1093/infdis/128.3.349.