百日咳：疾病与新诊断方法
Pertussis: the disease and new diagnostic methods.
作者信息
Friedman R L
机构信息
Department of Microbiology and Immunology, College of Medicine, University of Arizona, Tucson 85724.
出版信息
Clin Microbiol Rev. 1988 Oct;1(4):365-76. doi: 10.1128/CMR.1.4.365.
Abstract
Bordetella pertussis, the causative agent of whooping cough, produces an acute and chronic respiratory infection in infants and young children. B. pertussis is still a major health problem of young children throughout the world even though effective immunization against whooping cough is available. While predominantly a childhood disease, it has been reported also to be a cause of persistent cough in adults. This review discusses the numerous bacterial virulence factors that may play roles in the pathogenesis of pertussis and in immunity to infection. The present problems with pertussis diagnosis, recent advances, and future prospects for new and improved rapid diagnostics tests also are explored.
摘要
百日咳博德特氏菌是百日咳的病原体，可在婴幼儿中引起急性和慢性呼吸道感染。尽管有针对百日咳的有效疫苗，但百日咳博德特氏菌仍是全球幼儿面临的一个主要健康问题。虽然百日咳主要是一种儿童疾病，但也有报道称它是成人持续性咳嗽的一个病因。本综述讨论了众多可能在百日咳发病机制及抗感染免疫中发挥作用的细菌毒力因子。还探讨了百日咳诊断目前存在的问题、近期进展以及新型和改进型快速诊断测试的未来前景。
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