Department of Surgery, Division of Urologic Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO.
Department of Urologic Surgery, University of California Davis School of Medicine, Sacramento, CA.
Urology. 2023 Apr;174:42-47. doi: 10.1016/j.urology.2022.12.014. Epub 2022 Dec 24.
To determine risk factors and time course for repeat procedures after ureteroscopy (URS) or shockwave lithotripsy (SWL) procedure using a large employer-based claims database.
We identified all patients who underwent treatment for ureteral or renal stone with URS or SWL from January 1, 2007 to December 31, 2014 using the IBM MarketScan Commercial Database. Repeat stone procedure was evaluated after a 90-day grace period from the index procedure. Patients were followed until December 31, 2017. We performed multivariate analyses using Cox proportional hazards to determine independent risk factors for repeat procedure after the initial stone removal.
A total of 189,739 patients underwent a SWL or URS and were included in the study. The incidence of repeat procedure per 100 person years was 6.8, and 4.4 after SWL and URS, respectively. The median time to reoperation was 12.5 months for SWL and 14.6 months for URS. On multivariable analysis, SWL was associated with an increased risk of repeat procedure compared to URS. (HR = 1.63). Paralysis, neurogenic bladder and inflammatory bowel disease were also associated with an increased risk of repeat procedure (HR = 1.66, 1.40, and 1.36 respectively) CONCLUSION: In a large national cohort, patients with paralysis and neurogenic bladder had a significantly higher risk of repeat stone procedure. SWL was associated with higher risk of repeat procedure than URS. Urologists can use these data to identify and counsel patients at high risk for need for recurrent procedure.
使用大型雇主索赔数据库确定输尿管镜检查 (URS) 或体外冲击波碎石术 (SWL) 后重复手术的危险因素和时间进程。
我们使用 IBM MarketScan 商业数据库,从 2007 年 1 月 1 日至 2014 年 12 月 31 日,确定了所有接受 URS 或 SWL 治疗输尿管或肾结石的患者。在指数手术 90 天宽限期后,评估了重复结石手术。患者随访至 2017 年 12 月 31 日。我们使用 Cox 比例风险分析进行多变量分析,以确定初始结石清除后重复手术的独立危险因素。
共有 189739 名患者接受了 SWL 或 URS 治疗,并纳入了本研究。每 100 人年的重复手术发生率为 6.8%,SWL 和 URS 分别为 4.4%。SWL 再手术的中位时间为 12.5 个月,URS 为 14.6 个月。多变量分析显示,与 URS 相比,SWL 与重复手术的风险增加相关 (HR=1.63)。瘫痪、神经性膀胱和炎症性肠病也与重复手术的风险增加相关 (HR=1.66、1.40 和 1.36)。
在一个大型的全国队列中,瘫痪和神经性膀胱患者再次发生结石的风险显著增加。与 URS 相比,SWL 与更高的重复手术风险相关。泌尿科医生可以使用这些数据来识别和告知需要反复手术的高风险患者。