Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht University, 3508 GA, Utrecht, The Netherlands.
Clinical Cardiology Department, University Medical Center Utrecht, Utrecht University, 3508 GA, Utrecht, The Netherlands.
BMC Med. 2022 Dec 27;20(1):496. doi: 10.1186/s12916-022-02650-4.
Diastolic dysfunction of the left ventricle (LVDD) is equally common in elderly women and men. LVDD is a condition that can remain latent for a long time but is also held responsible for elevated left ventricular filling pressures and high pulmonary pressures that may result in (exercise-induced) shortness of breath. This symptom is the hallmark of heart failure with preserved ejection fraction (HFpEF) which is predominantly found in women as compared to men within the HF spectrum. Given the mechanistic role of LVDD in the development of HFpEF, we review risk factors and mechanisms that may be responsible for this sex-specific progression of LVDD towards HFpEF from an epidemiological point-of-view and propose future research directions.
老年女性和男性的左心室舒张功能障碍（LVDD）同样常见。LVDD 是一种可以长期潜伏的病症，但也会导致左心室充盈压升高和肺动脉高压，从而导致（运动引起的）呼吸急促。这种症状是射血分数保留的心力衰竭（HFpEF）的标志，与 HF 谱中的男性相比，HFpEF 主要在女性中发现。鉴于 LVDD 在 HFpEF 发展中的机械作用，我们从流行病学角度回顾了可能导致 LVDD 向 HFpEF 这种特定性别进展的危险因素和机制，并提出了未来的研究方向。
