Ma Liangliang, Chen Xuelin, Gao Maolong
Department of Infectious Diseases, Beijing Geriatric Hospital, Beijing, 100095, People's Republic of China.
Department of Science and Technology, Beijing Geriatric Hospital, Beijing, 100095, People's Republic of China.
Infect Drug Resist. 2022 Dec 21;15:7555-7564. doi: 10.2147/IDR.S381392. eCollection 2022.
To explore the risk factors of malnutrition in type 2 diabetes mellitus combined with pulmonary tuberculosis (PTB-T2DM) patients and further to provide a clinical research basis for the identification and prevention of malnutrition.
From January 2020 to February 2022, 307 adult patients diagnosed with PTB-T2DM were enrolled in this retrospective study. According to whether malnutrition occurred after 6 months of treatment, patients were divided into malnutrition group (n = 123) and non-malnutrition group (n = 184). The nutritional status of patients was evaluated according to the Micro-Nutrition Assessment Scale (MNA). Evaluation of indicators was performed, including general information, disease characteristics of PTB-T2DM and laboratory indicators.
Univariate logistic regression analysis showed that drinking, divorced, BMI <18.5kg/m, weight <45kg, waist circumference <79cm, hip circumference <88cm, waist-to-hip ratio <69.99, calf circumference <26kg, grip strength <28kg, NRS score ≥3, Hb <106g/L, Alb <29.00g/L, PA <48.00μmol/L, GHB <3.40%, serum transferrin <1.37 mmol/L, serum potassium <3.18mmol/L, serum sodium <142.95 mmol/L, FEV ≥67.90% and RV <2.89% were risk factors for malnutrition in PTB-T2DM patients (all < 0.05). The results of multivariate logistic regression analysis showed that drinking, divorced, weight <45kg, BMI <18.5kg/m, NRS score ≥3, Hb <106g/L, Alb <29.00g/L, PA <48.00μmol/L, serum transferrin <1.37mmol/L, FEV ≥67.90% and RV <2.89% were independent risk factors for malnutrition in PTB-T2DM patients (all < 0.05).
Drinking, divorced, weight <45kg, BMI <18.5kg/m, NRS score ≥3, Hb <106g/L, Alb <29.00g/L, PA <48.00μmol/L, serum transferrin <1.37mmol/L, FEV ≥67.90% and RV <2.89% may be independent risk factors for malnutrition in PTB-T2DM patients, and timely identification of high-risk groups could improve the prognosis of PTB-T2DM patients.
探讨2型糖尿病合并肺结核（PTB-T2DM）患者营养不良的危险因素，进而为营养不良的识别与预防提供临床研究依据。
选取2020年1月至2022年2月确诊为PTB-T2DM的307例成年患者进行这项回顾性研究。根据治疗6个月后是否发生营养不良，将患者分为营养不良组（n = 123）和非营养不良组（n = 184）。采用微型营养评定量表（MNA）评估患者的营养状况。进行指标评估，包括一般信息、PTB-T2DM的疾病特征和实验室指标。
单因素logistic回归分析显示，饮酒、离异、BMI<18.5kg/m、体重<45kg、腰围<79cm、臀围<88cm、腰臀比<69.99、小腿围<26kg、握力<28kg、NRS评分≥3、Hb<106g/L、Alb<29.00g/L、PA<48.00μmol/L、GHB<3.40%、血清转铁蛋白<1.37 mmol/L、血清钾<3.18mmol/L、血清钠<142.95 mmol/L、FEV≥67.90%和RV<2.89%是PTB-T2DM患者营养不良的危险因素（均P<0.05）。多因素logistic回归分析结果显示，饮酒、离异、体重<45kg、BMI<18.5kg/m、NRS评分≥3、Hb<106g/L、Alb<29.00g/L、PA<48.00μmol/L、血清转铁蛋白<1.37mmol/L、FEV≥67.90%和RV<2.89%是PTB-T2DM患者营养不良的独立危险因素（均P<0.05）。
饮酒、离异、体重<45kg、BMI<18.5kg/m、NRS评分≥3、Hb<106g/L、Alb<29.00g/L、PA<48.00μmol/L、血清转铁蛋白<1.37mmol/L、FEV≥67.90%和RV<2.89%可能是PTB-T2DM患者营养不良的独立危险因素，及时识别高危人群可改善PTB-T2DM患者的预后。
