幼鼠大肠杆菌感染与脑膜炎的动态变化
Dynamics of Escherichia coli infection and meningitis in infant rats.
作者信息
Bortolussi R, Ferrieri P, Wannamaker L W
出版信息
Infect Immun. 1978 Nov;22(2):480-5. doi: 10.1128/iai.22.2.480-485.1978.
Abstract
Escherichia coli strains isolated from newborn infants were injected intraperitoneally into infant rats. Strains possessing the K1 capsular polysaccharide antigen were significantly more virulent than strains lacking this antigen. When 5-day-old animals were injected with 1.2 X 10(1) colony forming units of a K1 E. coli strain (serotype O18ac:K1:H7), about 80% had bacteria isolated from their blood. Forty-eight percent of bacteremic animals had positive cerebrospinal fluid cultures. The development of bacteremia with greater than 10(4) colony-forming units per ml of blood correlated with positive cultures of cerebrospinal fluid. Some animals, studied with serial blood cultures, were able to clear bacteria spontaneously from their blood, whereas others succumbed to infection within 48 h of challenge. The susceptibility of infant rats to E. coli infection was age dependent and appeared related to the K1 antigen.
摘要
将从新生儿分离出的大肠杆菌菌株经腹腔注射到幼鼠体内。具有K1荚膜多糖抗原的菌株比缺乏该抗原的菌株毒力明显更强。给5日龄的动物注射1.2×10¹个菌落形成单位的K1大肠杆菌菌株（血清型O18ac:K1:H7）后，约80%的动物血液中分离出细菌。48%的菌血症动物脑脊液培养呈阳性。每毫升血液中菌落形成单位大于10⁴的菌血症发展与脑脊液培养阳性相关。一些通过连续血培养研究的动物能够自发清除血液中的细菌，而另一些在受到攻击后48小时内死于感染。幼鼠对大肠杆菌感染的易感性与年龄有关，且似乎与K1抗原有关。
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J Infect Dis. 1977 Aug;136 Suppl:S93-7. doi: 10.1093/infdis/136.supplement.s93.
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