From the National Institute of Occupational Health (STAMI), Oslo, Norway (M.S., Ø.S., D.M., S.E.H., E.G., and L.-K.L.); The Blood Cell Research Group, Department of Medical Biochemistry, Oslo University Hospital, Ullevaal, Norway (H.C.D.A.); Ostlandske Hjertesenter, Moss, Norway (P.A.S.); School of Health Sciences, Kristiania University College, Oslo, Norway (A.M.).
J Occup Environ Med. 2023 Apr 1;65(4):284-291. doi: 10.1097/JOM.0000000000002779. Epub 2022 Dec 29.
To assess changes in cardiovascular disease risk factors during a 3-year follow-up among 57 rotating shift workers and 29 day workers in industry.
We collected demographics by questionnaire, examined blood pressure, heart rate, pulse wave velocity, carotid media thickness, and maximal oxygen uptake. We assessed blood samples for determination of lipids, glycosylated hemoglobin, C-reactive protein, markers of inflammation, and particle concentrations/respirable dust. Baseline comparisons were analyzed using logistic regression (plaque) and linear regression for all other outcomes. We applied mixed models to assess differences in change in health outcomes between the shift workers and the day workers.
At baseline, the adhesion molecules soluble vascular cell adhesion molecule 1 and soluble P-selectin were elevated among the shift workers compared with that of the day workers. There was a significant difference in change in pulse wave velocity between shift workers (1.29-m/s increase) and day workers (0.11-m/s increase) over the 3-year follow-up. Respirable dust levels were below the Norwegian occupational exposure limit.
Shift work in industry is associated with arterial stiffening reflecting increased risk for future cardiovascular disease. More uncertainly, we found some support for systemic inflammation.
评估在工业领域中，3 年随访期间 57 名轮班工人和 29 名白班工人的心血管疾病危险因素变化情况。
我们通过问卷调查收集人口统计学资料，检测血压、心率、脉搏波速度、颈动脉内膜中层厚度和最大摄氧量。我们评估了血液样本，以确定血脂、糖化血红蛋白、C 反应蛋白、炎症标志物和颗粒浓度/可吸入粉尘。使用逻辑回归（斑块）和所有其他结果的线性回归分析基线比较。我们应用混合模型来评估轮班工人和白班工人之间健康结果变化的差异。
在基线时，与白班工人相比，轮班工人的粘附分子可溶性血管细胞粘附分子 1 和可溶性 P 选择素升高。在 3 年的随访期间，轮班工人的脉搏波速度变化（增加 1.29m/s）与白班工人（增加 0.11m/s）之间存在显著差异。可吸入粉尘水平低于挪威职业接触限值。
工业中的轮班工作与动脉僵硬有关，反映出未来心血管疾病风险增加。更不确定的是，我们发现一些支持全身炎症的证据。
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