心脏康复对冠心病患者血脂水平的影响：系统评价和荟萃分析。
The Effect of Cardiac Rehabilitation on Lipid Levels in Patients with Coronary Heart Disease. A Systematic Review and Meta-Analysis.
机构信息
Department of Cardiology, Bengbu second people's hospital, Bengbu, Anhui province, 233000, PR, China.
Bengbu second people's hospital, No. 302 of Yan' an Road, Bengbu, Anhui province, 233000, PR, China.
出版信息
Glob Heart. 2022 Nov 29;17(1):83. doi: 10.5334/gh.1170. eCollection 2022.
BACKGROUND
Cardiac rehabilitation (CR) is a multidisciplinary medical program. Most studies have emphasized the effect of exercise-based CR in lowering lipid levels; however, the effect of CR as a comprehensive program on lipid levels remains unclear.
METHODS
Electronic database were searched up to 2022. Randomized controlled trials with lipid profile indicators were included. Standardized mean differences (SMDs) and 95% CIs were used to evaluate the effect size. Begg's funnel plot and Egger's linear regression test were used to assess publication bias.
RESULTS
CR remarkably reduced low-density lipoprotein cholesterol (LDL-C) levels (SMD = -0.23; 95%CI: [-0.38, -0.08]; P < 0.001), triglyceride (TG) levels (SMD = -0.17; 95%CI: [-0.28, -0.06]; P < 0.001), and total cholesterol (TC) levels (SMD = -0.30; 95%CI: [-0.43, -0.16]; P < 0.001) and increased high-density lipoprotein cholesterol (HDL-C) levels (SMD = 0.19; 95%CI: [0.10, 0.29]; P < 0.001).
CONCLUSIONS
CR reduce TC, TG, and LDL-C levels while improving HDL-C levels. CR should be promoted and more trials should be conducted for long-term CR.
背景
心脏康复（CR）是一个多学科的医学项目。大多数研究都强调了基于运动的 CR 在降低血脂水平方面的效果；然而，CR 作为一个综合项目对血脂水平的影响尚不清楚。
方法
电子数据库检索至 2022 年。纳入了具有血脂指标的随机对照试验。使用标准化均数差值（SMD）和 95%置信区间（CI）来评估效应量。使用 Begg 漏斗图和 Egger 线性回归检验来评估发表偏倚。
结果
CR 显著降低了低密度脂蛋白胆固醇（LDL-C）水平（SMD = -0.23；95%CI：[-0.38，-0.08]；P < 0.001）、甘油三酯（TG）水平（SMD = -0.17；95%CI：[-0.28，-0.06]；P < 0.001）和总胆固醇（TC）水平（SMD = -0.30；95%CI：[-0.43，-0.16]；P < 0.001），并增加了高密度脂蛋白胆固醇（HDL-C）水平（SMD = 0.19；95%CI：[0.10，0.29]；P < 0.001）。
结论
CR 降低了 TC、TG 和 LDL-C 水平，同时提高了 HDL-C 水平。应该推广 CR，并进行更多的长期 CR 试验。
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