Bergamo Francesca, Dalla Santa Silvia, Loupakis Fotios, Cerma Krisida, Tosi Anna, De Grandis Caterina, Dalla Pietà Anna, Gringeri Enrico, Angerilli Valentina, Ramondo Gaetano, Rago Alessandro, Cecchi Fabiola, Benz Stephen, Cillo Umberto, Dei Tos Angelo Paolo, Zagonel Vittorina, Fassan Matteo, Rosato Antonio, Lonardi Sara
Oncology Unit 1, Department of Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.
Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy.
Front Oncol. 2022 Dec 8;12:964219. doi: 10.3389/fonc.2022.964219. eCollection 2022.
The current level of evidence for immunotherapy in previously untreated microsatellite unstable metastatic colorectal cancer is based on recent pieces of evidence of few studies that demonstrated durable response and clinical benefit, in terms of objective response rate, disease control rate, and progression-free survival in this subgroup of patients. On the basis of combinatorial immunotherapy with nivolumab plus ipilimumab, we report the exceptional case of a complete pathological response in a 21-year-old woman presenting a clinically aggressive stage IV colorectal cancer with massive nodal and liver involvement. Extensive molecular analyses based on whole genome next-generation DNA sequencing, RNA sequencing, fluorescent multiplex immunohistochemistry, and flow cytometry provided a detailed description of tumoral and immunological characteristics of this noteworthy clinical case.
免疫疗法用于既往未治疗的微卫星高度不稳定转移性结直肠癌的当前证据水平，是基于近期少数研究的证据，这些研究表明该亚组患者在客观缓解率、疾病控制率和无进展生存期方面有持久反应和临床获益。基于纳武利尤单抗联合伊匹木单抗的联合免疫疗法，我们报告了一例特殊病例，一名21岁女性患有临床侵袭性IV期结直肠癌，伴有大量淋巴结和肝脏受累，经治疗出现了完全病理缓解。基于全基因组下一代DNA测序、RNA测序、荧光多重免疫组化和流式细胞术的广泛分子分析，详细描述了这一值得关注的临床病例的肿瘤和免疫特征。
