Akanuma Haruna, Ueno Shin-Ichi, Tanaka Shoko, Matsuda Nozomu, Kanai Kazuaki
Neurology, Fukushima Medical University School of Medicine, Fukushima, JPN.
Neurology, Juntendo University School of Medicine, Tokyo, JPN.
Cureus. 2022 Nov 23;14(11):e31834. doi: 10.7759/cureus.31834. eCollection 2022 Nov.
Mollaret meningitis is a recurrent aseptic meningitis mostly caused by herpes simplex virus type 2. Other causes of the disease rarely exist, and its pathology is not well understood. Herein, we present a 57-year-old man who had been admitted to our hospital eight times with recurrent aseptic meningitis. Although the deoxyribonucleic acid (DNA) of varicella-zoster virus (VZV) was not detected in the cerebrospinal fluid (CSF), his genetic analysis, measurement of anti-VZV immunoglobulin-G (IgG) in the CSF, the VZV IgG index, IgG in the serum, and interleukin-1 beta in the CSF revealed that the Mollaret meningitis had been caused by the VZV. This case demonstrates that Mollaret meningitis can be caused by the VZV when specific factors are associated with decreased immune response. This case is valuable in elucidating the pathophysiology of Mollaret meningitis.
莫拉雷脑膜炎是一种复发性无菌性脑膜炎，主要由2型单纯疱疹病毒引起。该疾病的其他病因罕见，其病理机制尚不清楚。在此，我们报告一名57岁男性，因复发性无菌性脑膜炎八次入住我院。尽管脑脊液（CSF）中未检测到水痘-带状疱疹病毒（VZV）的脱氧核糖核酸（DNA），但对其进行的基因分析、CSF中抗VZV免疫球蛋白G（IgG）的测定、VZV IgG指数、血清IgG以及CSF中白细胞介素-1β的检测结果显示，该莫拉雷脑膜炎是由VZV引起的。该病例表明，当特定因素与免疫反应降低相关时，莫拉雷脑膜炎可由VZV引起。该病例对于阐明莫拉雷脑膜炎的病理生理学具有重要价值。
