Centre for Public Health and UKCRC Centre of Excellence for Public Health, Queen's University Belfast, Belfast, UK
Global Public Health, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Subang Jaya, Malaysia.
BMJ Open. 2022 Sep 1;12(9):e058420. doi: 10.1136/bmjopen-2021-058420.
Colorectal cancer (CRC) is the second most common cancer in Malaysia and cases are often detected late. Improving screening uptake is key in down-staging cancer and improving patient outcomes. The aim of this study is to develop, implement and evaluate an intervention to improve CRC screening uptake in Malaysia in the context of the COVID-19 pandemic. The evaluation will include ascertaining the budgetary impact of implementing and delivering the intervention.
The implementation research logic model guided the development of the study and implementation outcome measures were informed by the 'Reach, Effectiveness, Adoption, Implementation and Maintenance' (RE-AIM) framework. This CRC screening intervention for Malaysia uses home-testing and digital, small media, communication to improve CRC screening uptake. A sample of 780 people aged 50-75 years living in Segamat district, Malaysia, will be selected randomly from the South East Asia Community Observatory (SEACO) database. Participants will receive a screening pack as well as a WhatsApp video of a local doctor to undertake a stool test safely and to send a photo of the test result to a confidential mobile number. SEACO staff will inform participants of their result. Quantitative data about follow-up clinic attendance, subsequent hospital tests and outcomes will be collected. Logistic regression will be used to investigate variables that influence screening completion and we will conduct a budget impact-analysis of the intervention and its implementation. Qualitative data about intervention implementation from the perspective of participants and stakeholders will be analysed thematically.
Ethics approval has been granted by Monash University Human Research Ethics Committee (MUHREC ID: 29107) and the Medical Review and Ethics Committee (Reference: 21-02045-O7G(2)). Results will be disseminated through publications, conferences and community engagement activities.
National Medical Research Register Malaysia: 21-02045-O7G(2).
结直肠癌（CRC）是马来西亚第二常见的癌症，且病例通常发现较晚。提高筛查参与率是降期癌症和改善患者预后的关键。本研究旨在开发、实施和评估一项干预措施，以在 COVID-19 大流行背景下提高马来西亚的 CRC 筛查参与率。评估将包括确定实施和提供干预措施的预算影响。
实施研究逻辑模型指导了研究的开展，实施结果衡量指标则由“可达性、有效性、采纳度、实施度和维持度”（RE-AIM）框架提供信息。这项针对马来西亚的 CRC 筛查干预措施使用家庭检测和数字、小型媒体、传播来提高 CRC 筛查参与率。将从东南亚社区观察站（SEACO）数据库中随机抽取 780 名年龄在 50-75 岁之间居住在马来西亚士古来区的人作为样本。参与者将收到一个筛查包，以及一个当地医生的 WhatsApp 视频，以便安全地进行粪便检测，并将检测结果的照片发送到一个保密的手机号码。SEACO 工作人员将告知参与者他们的检测结果。将收集有关后续就诊、后续医院检查和结果的定量数据。将使用逻辑回归来调查影响筛查完成的变量，我们将对干预措施及其实施进行预算影响分析。将从参与者和利益相关者的角度对干预实施的定性数据进行主题分析。
莫纳什大学人类研究伦理委员会（MUHREC ID：29107）和医疗审查和伦理委员会（参考号：21-02045-O7G(2)）已批准伦理。结果将通过出版物、会议和社区参与活动进行传播。
马来西亚国家医学研究注册处：21-02045-O7G(2)。
