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长期类似时差反应的状况会使伏隔核和前额叶皮质中神经疾病的分子特征失调。

Chronic jet lag-like conditions dysregulate molecular profiles of neurological disorders in nucleus accumbens and prefrontal cortex.

作者信息

Siddique Rabeea, Awan Faryal Mehwish, Nabi Ghulam, Khan Suliman, Xue Mengzhou

机构信息

Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Henan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, Henan, China.

出版信息

Front Neuroinform. 2022 Dec 13;16:1031448. doi: 10.3389/fninf.2022.1031448. eCollection 2022.

DOI:10.3389/fninf.2022.1031448
PMID:36582489
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9792783/
Abstract

BACKGROUND

Patients with neurological disorders often display altered circadian rhythms. The disrupted circadian rhythms through chronic jetlag or shiftwork are thought to increase the risk and severity of human disease including, cancer, psychiatric, and related brain diseases.

RESULTS

In this study, we investigated the impact of shiftwork or chronic jetlag (CJL) like conditions on mice's brain. Transcriptome profiling based on RNA sequencing revealed that genes associated with serious neurological disorders were differentially expressed in the nucleus accumbens (NAc) and prefrontal cortex (PFC). According to the quantitative PCR (qPCR) analysis, several key regulatory genes associated with neurological disorders were significantly altered in the NAc, PFC, hypothalamus, hippocampus, and striatum. Serotonin levels and the expression levels of serotonin transporters and receptors were significantly altered in mice treated with CJL.

CONCLUSION

Overall, these results indicate that CJL may increase the risk of neurological disorders by disrupting the key regulatory genes, biological functions, serotonin, and corticosterone. These molecular linkages can further be studied to investigate the mechanism underlying CJL or shiftwork-mediated neurological disorders in order to develop treatment strategies.

摘要

背景

神经系统疾病患者常表现出昼夜节律改变。因长期时差反应或轮班工作导致的昼夜节律紊乱被认为会增加包括癌症、精神疾病及相关脑部疾病在内的人类疾病的风险和严重程度。

结果

在本研究中，我们调查了轮班工作或类似长期时差反应（CJL）的情况对小鼠大脑的影响。基于RNA测序的转录组分析显示，与严重神经系统疾病相关的基因在伏隔核（NAc）和前额叶皮质（PFC）中差异表达。根据定量PCR（qPCR）分析，与神经系统疾病相关的几个关键调控基因在NAc、PFC、下丘脑、海马体和纹状体中显著改变。CJL处理的小鼠血清素水平以及血清素转运体和受体的表达水平显著改变。

结论

总体而言，这些结果表明，CJL可能通过破坏关键调控基因、生物学功能、血清素和皮质酮来增加神经系统疾病的风险。可以进一步研究这些分子联系，以探究CJL或轮班工作介导的神经系统疾病的潜在机制，从而制定治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa2c/9792783/c39a9dd772d4/fninf-16-1031448-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa2c/9792783/33766a8caaa6/fninf-16-1031448-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa2c/9792783/847bc77d0ba7/fninf-16-1031448-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa2c/9792783/91fb5e7ee7c2/fninf-16-1031448-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa2c/9792783/fb15e1de2429/fninf-16-1031448-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa2c/9792783/9a7e091526cb/fninf-16-1031448-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa2c/9792783/8d3e89bc9e60/fninf-16-1031448-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa2c/9792783/c9a64b8f4f29/fninf-16-1031448-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa2c/9792783/c39a9dd772d4/fninf-16-1031448-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa2c/9792783/33766a8caaa6/fninf-16-1031448-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa2c/9792783/847bc77d0ba7/fninf-16-1031448-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa2c/9792783/91fb5e7ee7c2/fninf-16-1031448-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa2c/9792783/fb15e1de2429/fninf-16-1031448-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa2c/9792783/9a7e091526cb/fninf-16-1031448-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa2c/9792783/8d3e89bc9e60/fninf-16-1031448-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa2c/9792783/c9a64b8f4f29/fninf-16-1031448-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa2c/9792783/c39a9dd772d4/fninf-16-1031448-g008.jpg

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