Acosta Julieta, Crespo Manuel T, Plano Santiago A, Golombek Diego A, Chiesa Juan J, Agostino Patricia V
Department of Science and Technology, Universidad Nacional de Quilmes/CONICET, Buenos Aires, Argentina.
Institute for Biomedical Research (BIOMED), Universidad Católica Argentina (UCA)/CONICET, Buenos Aires, Argentina.
Front Physiol. 2023 Sep 6;14:1225134. doi: 10.3389/fphys.2023.1225134. eCollection 2023.
The circadian system regulates various physiological processes such as sleep-wake cycles, hormone secretion, metabolism, and the reaction to both natural and drug-based rewards. Chronic disruption of the circadian system caused by unsteady synchronization with light-dark (LD) schedules, such as advancing chronic jet lag (CJL), leads to adverse physiological effects and pathologies, and is linked with changes in mood and depressive behaviors in humans and rodent models. C57BL/6J male mice were subjected to circadian disruption through phase advances of 6 h every 2 days (CJL +6/2). Mice under 12:12-h LD cycle were used as controls. After 8 weeks under these conditions, a battery of behavioral tests was performed to assess if mood-related behaviors were affected. Compared to controls under 24 h LD cycles, mice under CJL presented desynchronization of activity-rest rhythms that led to several behavioral impairments, including a decrease in motivation for food reward, and an increase in anxiety, anhedonia, and depressive-like behavior. Chronic circadian disruption, caused by an experimental CJL protocol, affects mood-related and reward-related behaviors in mice. Understanding the importance of the circadian system and its potential role for disruption due to CJL is important for maintaining good health and well-being.
昼夜节律系统调节各种生理过程，如睡眠-觉醒周期、激素分泌、新陈代谢以及对自然奖励和药物奖励的反应。与明暗（LD）周期的不稳定同步导致的昼夜节律系统长期紊乱，如长期时差提前（CJL），会导致不良生理影响和病理变化，并与人类和啮齿动物模型中的情绪变化和抑郁行为有关。C57BL/6J雄性小鼠通过每2天提前6小时的相位推进来经历昼夜节律紊乱（CJL +6/2）。处于12:12小时LD周期的小鼠用作对照。在这些条件下饲养8周后，进行了一系列行为测试，以评估与情绪相关的行为是否受到影响。与24小时LD周期下的对照组相比，CJL组小鼠的活动-休息节律不同步，导致了一些行为障碍，包括食物奖励动机降低、焦虑增加、快感缺失和抑郁样行为。由实验性CJL方案引起的慢性昼夜节律紊乱会影响小鼠与情绪相关和与奖励相关的行为。了解昼夜节律系统的重要性及其因CJL而破坏的潜在作用对于维持良好的健康和幸福至关重要。
