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使用诺沃索尔可生物降解临时基质修复近全头皮撕脱伤:儿科病例报告

Reconstruction of a Near-total Scalp Avulsion with NovoSorb Biodegradable Temporizing Matrix: Pediatric Case Report.

作者信息

Patel Niki K, Tipps John A, Graham Emily M, Taylor Jesse A, Mendenhall Shaun D

机构信息

Division of Plastic, Reconstructive, and Oral Surgery, Children's Hospital of Philadelphia, Philadelphia, Pa.

Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa.

出版信息

Plast Reconstr Surg Glob Open. 2022 Dec 13;10(12):e4717. doi: 10.1097/GOX.0000000000004717. eCollection 2022 Dec.

Abstract

Traumatic dog bites of the face and head are common among the pediatric population, although injuries resulting in total or subtotal scalp avulsions are rare and life-threatening. Standard treatment in these cases includes attempts at replantation or free tissue transfer; however, these procedures may not always be possible. An alternative treatment option involves the use of dermal substitutes, such as Integra (Integra LifeScience Corporation), with subsequent skin grafting. More recently, an alternative skin substitute called NovoSorb Biodegradable Temporizing Matrix (BTM) (PolyNovo North America LLC) has displayed favorable reconstructive outcomes in recent burn literature. NovoSorb BTM is a novel, fully synthetic bilayer scaffold made of biodegradable polyurethane matrix covered with a sealing membrane. In this report, the authors describe a 3-year-old boy who presented emergently with a severe dog bite avulsion to the subpericranial level of approximately 80% of his scalp, which was not replantable. The surgical plan involved a staged reconstruction using Integra and later skin grafting. Purulent infection ensued and required removal of Integra less than 2 weeks from application. Upon clearing of the infection, the wound was successfully closed with BTM and subsequent skin grafting. With proper wound management and over 6 months of follow-up, the patient experienced excellent healing of the graft with stable calvarial coverage and an acceptable aesthetic outcome. He will undergo tissue expansion of the remaining hair-bearing scalp in the future.

摘要

面部和头部的创伤性犬咬伤在儿科人群中很常见,尽管导致头皮完全或部分撕脱的损伤很少见且危及生命。这些病例的标准治疗方法包括尝试再植或游离组织移植;然而,这些手术并非总是可行。一种替代治疗选择是使用真皮替代物,如Integra(英特格拉生命科学公司),随后进行皮肤移植。最近,一种名为NovoSorb可生物降解临时基质(BTM)(PolyNovo北美有限责任公司)的替代皮肤替代物在最近的烧伤文献中显示出良好的重建效果。NovoSorb BTM是一种新型的、完全合成的双层支架,由覆盖有密封膜的可生物降解聚氨酯基质制成。在本报告中,作者描述了一名3岁男孩,他因严重的犬咬伤导致头皮约80%的颅骨下水平撕脱,无法再植而紧急就诊。手术方案包括使用Integra进行分期重建,随后进行皮肤移植。随后发生了脓性感染,需要在应用Integra后不到2周将其移除。感染清除后,伤口用BTM和随后的皮肤移植成功闭合。通过适当的伤口处理和6个多月的随访,患者移植部位愈合良好,颅骨覆盖稳定,美学效果可接受。他未来将对剩余有毛发的头皮进行组织扩张。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a86/9750680/e311a1b735e0/gox-10-e4717-g001.jpg

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