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用于鼻整形重建的诺沃索尔可生物降解临时基质(PolyNovo):酒渣鼻皮肤重建病例报告

NovoSorb Biodegradable Temporizing Matrix (PolyNovo) for Aesthetic Nasal Reconstruction: A Case Report of Rhinophyma Resurfacing.

作者信息

Kyriazidis Ioannis, Demiri Efterpi, Lazaridou Alexandra, Pavlidis Leonidas, Papas Athanasios

机构信息

Department of Plastic and Reconstructive Surgery, General Hospital Papageorgiou, Thessaloniki, GRC.

Department of Plastic and Reconstructive Surgery, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, GRC.

出版信息

Cureus. 2025 Jul 10;17(7):e87678. doi: 10.7759/cureus.87678. eCollection 2025 Jul.

DOI:10.7759/cureus.87678
PMID:40786324
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12335319/
Abstract

Rhinophyma, a severe form of rosacea, causes significant nasal disfigurement, posing challenges for aesthetic reconstruction after excision. This case report details the novel application of PolyNovo's NovoSorb biodegradable temporizing matrix (BTM), a synthetic dermal substitute, for aesthetic nasal reconstruction following rhinophyma excision and utilizing secondary intention healing. A 65-year-old male with progressive rhinophyma underwent tangential excision and burring. A tailored piece of NovoSorb BTM was applied and secured to the defect. Postoperative care involved paraffin gauze. The patient exhibited excellent aesthetic results with minimal scarring. Outcome measures, including the FACE-Q Skin Cancer Module and the Dermatology Life Quality Index (DLQI), demonstrated significant improvements in appearance-related concerns, psychosocial well-being, and daily functioning. This report highlights the innovative use of NovoSorb BTM and secondary intention healing for rhinophyma reconstruction. The successful outcome, supported by validated patient-reported outcome measures, suggests that BTM may be a valuable tool in similar cases, offering a new avenue for achieving both functional and aesthetic goals.

摘要

酒渣鼻性痤疮是酒渣鼻的一种严重形式,会导致严重的鼻部畸形,给切除后的美学重建带来挑战。本病例报告详细介绍了PolyNovo公司的NovoSorb可生物降解临时基质(BTM)(一种合成真皮替代物)在酒渣鼻性痤疮切除术后利用二期愈合进行美学鼻部重建中的新颖应用。一名患有进行性酒渣鼻性痤疮的65岁男性接受了削除术和打磨术。将一块定制的NovoSorb BTM应用于缺损处并固定。术后护理包括使用石蜡纱布。患者取得了极佳的美学效果,疤痕极小。包括面部Q皮肤癌模块和皮肤病生活质量指数(DLQI)在内的结果指标显示,在外观相关问题、心理社会幸福感和日常功能方面有显著改善。本报告强调了NovoSorb BTM和二期愈合在酒渣鼻性痤疮重建中的创新应用。经验证的患者报告结果指标支持的成功结果表明,BTM在类似病例中可能是一种有价值的工具,为实现功能和美学目标提供了一条新途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d33a/12335319/05ec7412cb06/cureus-0017-00000087678-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d33a/12335319/b1b2bea1ff0b/cureus-0017-00000087678-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d33a/12335319/6c6a82aae6df/cureus-0017-00000087678-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d33a/12335319/2e2769862012/cureus-0017-00000087678-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d33a/12335319/05ec7412cb06/cureus-0017-00000087678-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d33a/12335319/b1b2bea1ff0b/cureus-0017-00000087678-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d33a/12335319/6c6a82aae6df/cureus-0017-00000087678-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d33a/12335319/2e2769862012/cureus-0017-00000087678-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d33a/12335319/05ec7412cb06/cureus-0017-00000087678-i04.jpg

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本文引用的文献

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The Use of Novosorb Biodegradable Temporizing Matrix for Reconstruction in Head and Neck Cancer: A Simple Answer to a Complex Problem.诺沃索尔可生物降解临时基质在头颈癌重建中的应用:复杂问题的简单解决方案
Plast Reconstr Surg Glob Open. 2025 Apr 29;13(4):e6702. doi: 10.1097/GOX.0000000000006702. eCollection 2025 Apr.
2
Biodegradable Temporizing Matrix in Postoncological Scalp Reconstruction: A Case Series.生物可降解临时基质在肿瘤后头皮重建中的应用:病例系列
Plast Reconstr Surg Glob Open. 2025 Jan 28;13(1):e6497. doi: 10.1097/GOX.0000000000006497. eCollection 2025 Jan.
3
Secondary Healing Over NovoSorb BTM in the Management of Complex Nasal Defects.
在复杂鼻缺损治疗中,NovoSorb BTM上的二期愈合
Plast Reconstr Surg Glob Open. 2025 Jan 27;13(1):e6492. doi: 10.1097/GOX.0000000000006492. eCollection 2025 Jan.
4
The Efficacy of Biodegradable Temporising Matrix for Upper Limb Reconstruction: A Systematic Review and Meta-Analysis.可生物降解临时基质用于上肢重建的疗效:系统评价与Meta分析
Cureus. 2024 Dec 19;16(12):e75994. doi: 10.7759/cureus.75994. eCollection 2024 Dec.
5
Novosorb BTM- history, production and application in challenging wounds.诺沃索布生物可吸收临时基质——历史、生产及在难愈伤口中的应用
Front Bioeng Biotechnol. 2024 Nov 13;12:1450973. doi: 10.3389/fbioe.2024.1450973. eCollection 2024.
6
Use of Biodegradeable Temporizing Matrix Dermal Template for Reconstruction of Upper Extremity Soft Tissue Defects with Associated Tendon Injury.可生物降解临时基质真皮模板用于重建伴有肌腱损伤的上肢软组织缺损
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