戊四氮诱导小鼠癫痫发作中[具体物质]各组分的神经保护作用 。 需注意，原文中“the fractions of ”部分表述不完整，缺少具体物质。
Neuroprotective effects of the fractions of in seizures induced by pentylenetetrazole in mice.
作者信息
Mansouri Somaieh, Hosseini Mahmoud, Alipour Fatemeh, Beheshti Farimah, Rakhshandeh Hassan, Mohammadipour Abbas, Anaeigoudari Akbar, Jalili-Nik Mohammad, Khazdair Mohammad Reza, Jahani Amirali
机构信息
Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Anatomy, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.
出版信息
Avicenna J Phytomed. 2022 Nov-Dec;12(6):614-626. doi: 10.22038/AJP.2022.20470.
OBJECTIVE
Neuroprotective and antioxidant effects of against pentylenetetrazole (PTZ)-induced seizures were investigated.
MATERIALS AND METHODS
Mice were divided as follows: (Group 1) Control, (Group 2) PTZ, (Groups 3-5) 50,100 and 200 mg/kg hydro-ethanolic (HE) extract, and (Groups 6-8) 200 mg/kg ethyl-acetate (EAF), N-hexane (NHF) and water (WF) fractions. Minimal clonic seizures (MCS) and generalized tonic-clonic seizures (GTCS) latencies were measured. Biochemical and histological studies were done.
RESULTS
MCS and GTCS latency in HE groups were longer than the PTZ group (p<0.05 to p<0.001). EAF and NHF prolonged the onset of MCS and GTCS (p<0.001). PTZ increased malondialdehyde (MDA) and dark neuron (DN) production while decreased thiol, catalase (CAT) and superoxide dismutase (SOD) (p<0.05 to p<0.001). Pre-treatment by HE and all fractions of the plant attenuated MDA and DN while increased thiol, CAT and SOD (p<0.01 to p<0.001).
CONCLUSION
EAF and NHF had anticonvulsant properties. The extract and fractions protected the brain from PTZ-induced oxidative damages and showed neuroprotective effects.
目的
研究[提取物名称未给出]对戊四氮（PTZ）诱导的癫痫发作的神经保护和抗氧化作用。
材料与方法
将小鼠分为以下几组：（第1组）对照组，（第2组）PTZ组，（第3 - 5组）50、100和200 mg/kg水乙醇（HE）提取物组，以及（第6 - 8组）200 mg/kg乙酸乙酯（EAF）、正己烷（NHF）和水（WF）馏分组。测量最小阵挛性发作（MCS）和全身强直阵挛性发作（GTCS）的潜伏期。进行生化和组织学研究。
结果
HE组的MCS和GTCS潜伏期长于PTZ组（p<0.05至p<0.001）。EAF和NHF延长了MCS和GTCS的发作时间（p<0.001）。PTZ增加了丙二醛（MDA）和暗神经元（DN）的产生，同时降低了硫醇、过氧化氢酶（CAT）和超氧化物歧化酶（SOD）（p<0.05至p<0.001）。HE和该植物的所有馏分预处理可减轻MDA和DN，同时增加硫醇、CAT和SOD（p<0.01至p<0.001）。
结论
EAF和NHF具有抗惊厥特性。提取物和馏分可保护大脑免受PTZ诱导的氧化损伤，并显示出神经保护作用。
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