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一株内生真菌 TM-Y1-1 的新生物碱。

A new alkaloid from endophytic fungus sp. TM-Y1-1.

机构信息

School of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, GDMPA Key Laboratory for Process Control and Quality Evaluation of Chiral Pharmaceuticals, South China Normal University, Guangzhou 510000, China.

出版信息

J Asian Nat Prod Res. 2023 Sep;25(9):905-911. doi: 10.1080/10286020.2022.2162887. Epub 2022 Dec 30.

Abstract

A new alkaloid (), together with three known compounds, were isolated from the endophytic fungus TM-Y1-1. Their structures were elucidated by extensive spectroscopic methods. The absolute configuration of compound was determined for the first time by ECD calculation and DP4+ analysis. All compounds were evaluated for antimicrobial activity. The results showed that compounds and both exhibited moderate inhibitory activity against banana with MIC value of 31.25 μg/ml.

摘要

一种新的生物碱 (),与三种已知化合物一起,从内生真菌 TM-Y1-1 中分离得到。通过广泛的光谱方法阐明了它们的结构。化合物的绝对构型是通过 ECD 计算和 DP4+分析首次确定的。所有化合物均进行了抗菌活性评价。结果表明,化合物 和 对香蕉均具有中等抑制活性,MIC 值为 31.25μg/ml。

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