用于定向C-O键官能化的无痕酰基等价物——吡啶基亚胺酯
-Pyridylimidates as Traceless Acyl Equivalents for Directed C-O Bond Functionalization.
作者信息
Underwood Steven J, Douglas Christopher J
机构信息
Department of Chemistry, University of Minnesota-Twin Cities, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, United States.
出版信息
Org Lett. 2023 Jan 13;25(1):146-151. doi: 10.1021/acs.orglett.2c03961. Epub 2022 Dec 30.
Directing groups are a common strategy to target traditionally inert bonds, with an easily removable directing group being ideal. Herein we disclose our method for rhodium-catalyzed C-O bond functionalization of -pyridylimidates using a recyclable and traceless amine directing group. In addition to the substrate scope, we discuss the behavior of this class of compounds and how that behavior affects their reactivity.
导向基团是一种用于活化传统惰性键的常用策略，其中易于去除的导向基团最为理想。在此，我们报道了一种使用可回收且无痕的胺导向基团，通过铑催化的吡啶基亚氨酸酯的C-O键官能化方法。除了底物范围外，我们还讨论了这类化合物的性质及其性质如何影响它们的反应活性。
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