Mauriello J A, Coniaris H, Haupt E J
Department of Ophthalmology, UMDNJ-New Jersey Medical School, Eye Institute of New Jersey, Newark 07107.
Ophthalmology. 1987 Aug;94(8):976-9. doi: 10.1016/s0161-6420(87)33337-8.
One hundred patients with involuntary eyelid and facial spasms resulting from essential blepharospasm, Meige syndrome, and hemifacial spasm continued to respond to repeated injections of botulinum toxin at expected time intervals during a 30-month period. This series of more than 372 injections done by one of us (JAM) supports the finding of earlier, smaller series that tolerance to the toxin does not develop. The drug had a greater duration of effect in patients with hemifacial spasm than in patients with blepharospasm; the duration of effect was 17.25 weeks in the former group and 12.6 weeks in the latter. Eighteen percent of patients required a higher than standard dose for a therapeutic response. Fourteen of 15 patients with lower facial spasms and one patient with torticollis had significant relief. Dry eye may be managed by titrating the lower lid dose.
100例因原发性睑痉挛、Meige综合征和半面痉挛导致的不自主眼睑和面部痉挛患者，在30个月的时间里，按预期时间间隔反复注射肉毒杆菌毒素后仍持续有反应。我们其中一人（JAM）进行的这一系列超过372次注射，支持了早期较小系列研究的发现，即不会产生对该毒素的耐受性。该药物在半面痉挛患者中的作用持续时间比睑痉挛患者更长；前一组的作用持续时间为17.25周，后一组为12.6周。18%的患者需要高于标准剂量才能获得治疗反应。15例面下部痉挛患者中的14例和1例斜颈患者有明显缓解。干眼可通过调整下睑剂量来处理。
