Kraft S P, Lang A E
Department of Ophthalmology, University of Toronto, Ontario, Canada.
Can J Neurol Sci. 1988 Aug;15(3):276-80. doi: 10.1017/s0317167100027748.
Seventy-six patients with blepharospasm (mean age 56.9 years) received 248 injection treatments with botulinum A exotoxin (mean 3.1 treatments per patient): 87.0% of treatments led to total relief of spasms for a mean interval of 14.1 weeks. The average duration of response remained fairly constant over the first six injection series, although patients with the most severe spasms had shorter intervals than patients with less severe symptoms. Twenty patients with hemifacial spasm (mean age 56.9 years) received 44 treatments (mean 1.9 treatments per patient): In 93.1% of cases there was total relief of periocular and perioral spasms, with a mean interval of 17.4 weeks. The average duration of response for the third series of treatments was much shorter than the mean durations for the first two treatments. Side effects were always transient and included ptosis (23.3%), dry eyes (18.1%), tearing (5.5%), and strabismus (1.4%). No patient had a systemic reaction to the drug. Chronic benign eyelid fasciculations were also successfully treated in 3 patients with single treatments.
76例眼睑痉挛患者（平均年龄56.9岁）接受了248次A型肉毒杆菌外毒素注射治疗（平均每位患者3.1次治疗）：87.0%的治疗使痉挛完全缓解，平均缓解期为14.1周。在前六个注射疗程中，平均反应持续时间保持相当稳定，尽管痉挛最严重的患者缓解期比症状较轻的患者短。20例面肌痉挛患者（平均年龄56.9岁）接受了44次治疗（平均每位患者1.9次治疗）：93.1%的病例中眼周和口周痉挛完全缓解，平均缓解期为17.4周。第三个疗程的平均反应持续时间比前两个疗程的平均持续时间短得多。副作用均为短暂性，包括上睑下垂（23.3%）、干眼（18.1%）、流泪（5.5%）和斜视（1.4%）。没有患者对该药物产生全身反应。3例慢性良性眼睑肌束震颤患者单次治疗也取得成功。
