Covid-19 及其与人类眼睛的关系:传播、感染和眼部表现。

Covid-19 and its relation to the human eye: transmission, infection, and ocular manifestations.

机构信息

Ophthalmology, Royal Surrey County Hospital, Egerton Rd, Guildford, GU2 7XX, UK.

Department of Microbiology and Immunology, Faculty of Pharmacy, Future University in Egypt, Cairo, Egypt.

出版信息

Graefes Arch Clin Exp Ophthalmol. 2023 Jul;261(7):1771-1780. doi: 10.1007/s00417-022-05954-6. Epub 2022 Dec 31.

Abstract

BACKGROUND

The world is suffering from a new strain of the coronavirus family-Covid-19. This virus strain affected different organs in the human body with a wide range of mild symptoms and moderate signs to severe and deadly ones. Multiple organs can be infected, and one of these organs is the eye. The eye is a vital organ that consists of vascular tissues and is connected to the respiratory tract through the tears and the nasolacrimal duct.

METHODS

Recent papers and research from PubMed, Researchgate, and Google Scholar were cited and thoroughly discussed. These papers were chosen based on their relevancy, reliability, publication year, published journal, and ease of accessibility to the paper itself.

RESULTS

The theory concluded that the ocular surface might consider a pathway for the virus attack and infection causation through the tears and the angiotensin-converting enzyme 2 located in the eye. This article thoroughly reviewed the history, the existing aspects of Covid-19, the ocular system features, and the claims about the possible involvement of the eye in the virus transmission along with the eye infection. There was no consensus on the eye's involvement theory.

CONCLUSION

The authors highlighted the extra work and research needed to be conducted to prove or deny these claims to provide a better understanding of the immune response of the eye to Covid-19 infection.

摘要

背景

世界正遭受新型冠状病毒家族——新冠病毒的侵袭。这种病毒株会影响人体的不同器官,症状从轻微到中度,再到严重甚至致命,范围很广。多个器官可能受到感染,其中一个器官就是眼睛。眼睛是一个重要的器官,由血管组织构成,通过泪液和鼻泪管与呼吸道相连。

方法

本文引用了来自 PubMed、Researchgate 和 Google Scholar 的最新论文和研究,并进行了深入讨论。这些论文是根据其相关性、可靠性、出版年份、出版期刊以及获取论文本身的难易程度选择的。

结果

该理论认为,病毒可能通过眼泪和眼睛中的血管紧张素转换酶 2 攻击和感染眼部表面。本文全面回顾了新冠病毒的历史、现有情况、眼部系统特征以及关于眼睛在病毒传播和感染中可能发挥作用的说法。目前还没有关于眼睛感染理论的共识。

结论

作者强调需要开展更多的工作和研究,以证明或否定这些说法,从而更好地了解眼睛对新冠病毒感染的免疫反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2076/9803899/5ecea94a8699/417_2022_5954_Fig1_HTML.jpg

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