SeyedAlinaghi SeyedAhmad, Mehraeen Esmaeil, Afzalian Arian, Dashti Mohsen, Ghasemzadeh Afsaneh, Pashaei Ava, Masoud Afsahi Amir, Saeed Tamehri Zadeh Seyed, Amiri Fard Iman, Vafaee AmirMohammad, Molla Ayoob, Shahidi Ramin, Dadjou Ali, Amin Habibi Mohammad, Mirzapour Pegah, Dadras Omid
Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran.
Department of Health Information Technology, Khalkhal University of Medical Sciences, Khalkhal, Iran.
Prev Med Rep. 2024 Jan 14;38:102608. doi: 10.1016/j.pmedr.2024.102608. eCollection 2024 Feb.
COVID-19 caused by SARS-CoV-2, commonly presents with symptoms such as fever and shortness of breath but can also affect other organs. There is growing evidence pointing to potential eye complications. In this article, we aim to systematically review the ocular manifestations of COVID-19.
We conducted a systematic review to explore the ocular manifestations of COVID-19. We searched online databases including PubMed, Embase, Scopus, and Web of Science up to September 4, 2023. After a two-stage screening process and applying inclusion/exclusion criteria, eligible articles were advanced to the data extraction phase. The PRISMA checklist and Newcastle-Ottawa Scale (NOS) were used for quality and bias risk assessments.
We selected and extracted data from 42 articles. Most of the studies were cross-sectional (n = 33), with the highest number conducted in Turkey (n = 10). The most frequent ocular manifestation was conjunctivitis, reported in 24 articles, followed by photophobia, burning, chemosis, itching, and ocular pain. Most studies reported complete recovery from these manifestations; however, one study mentioned visual loss in two patients.
In general, ocular manifestations of COVID-19 appear to resolve either spontaneously or with supportive treatments. For more severe cases, both medical treatment and surgery have been employed, with the outcomes suggesting that complete recoveries are attainable.
由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的冠状病毒病2019（COVID-19）通常表现为发热和呼吸急促等症状，但也可能影响其他器官。越来越多的证据表明存在潜在的眼部并发症。在本文中，我们旨在系统回顾COVID-19的眼部表现。
我们进行了一项系统回顾，以探索COVID-19的眼部表现。我们检索了截至2023年9月4日的在线数据库，包括PubMed、Embase、Scopus和科学网。经过两阶段筛选过程并应用纳入/排除标准后，符合条件的文章进入数据提取阶段。采用系统评价和Meta分析的首选报告项目（PRISMA）清单和纽卡斯尔-渥太华量表（NOS）进行质量和偏倚风险评估。
我们从42篇文章中筛选并提取了数据。大多数研究为横断面研究（n = 33），其中数量最多的研究在土耳其进行（n = 10）。最常见的眼部表现是结膜炎，24篇文章中有报道，其次是畏光、烧灼感、结膜水肿、瘙痒和眼痛。大多数研究报告这些表现可完全恢复；然而，一项研究提到两名患者出现视力丧失。
一般来说，COVID-19的眼部表现似乎可自发缓解或通过支持性治疗缓解。对于更严重的病例，已采用药物治疗和手术治疗，结果表明可以实现完全康复。
