Department of Imaging Research, King Abdullah International Medical Research Center, Riyadh, 11481, Saudi Arabia.
King Saud bin Abdulaziz University for Health Sciences, 14611, Riyadh, Saudi Arabia.
Int Health. 2022 Mar 2;14(2):113-121. doi: 10.1093/inthealth/ihab028.
There is currently a lack of information regarding ocular tropism and the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Globally, the cumulative number of coronavirus disease 2019 (COVID-19) cases is increasing daily. Thus the potential for ocular transmission and manifestations of SARS-CoV-2 requires more investigation.
A systematic search of electronic databases for ocular transmission and manifestations of SARS-CoV-2 was performed. Pooled cross-sectional studies were used for conducting a meta-analysis to estimate the prevalence of ocular transmission of SARS-CoV-2 to the respiratory system and ocular manifestations (associated symptoms) of SARS-CoV-2.
The highest prevalence of SARS-CoV-2-positive tears using reverse transcription polymerase chain reaction was found to be 7.5%. However, the highest prevalence of ocular conjunctivitis associated with SARS-CoV-2 was 32%. Thus, SARS-CoV-2 can evidently infect the eye, as revealed in the conjunctival secretions of COVID-19 patients.
The available data reflect the influence of the ocular structure on SARS-CoV-2. The analysis showed that ocular manifestation is an indication for SARS-CoV-2, particularly conjunctivitis. Moreover, there is no evidence that the ocular structure can be an additional path of transmission for SARS-CoV-2, however, it warrants further investigation.
目前关于眼向性和严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）的信息有限。在全球范围内，新冠肺炎（COVID-19）病例的累计数量每天都在增加。因此，需要更多地研究 SARS-CoV-2 的眼部传播和表现。
对电子数据库中 SARS-CoV-2 的眼部传播和表现进行了系统搜索。采用汇总横断面研究进行荟萃分析，以估计 SARS-CoV-2 对呼吸系统的眼部传播和 SARS-CoV-2 的眼部表现（相关症状）的患病率。
使用逆转录聚合酶链反应发现 SARS-CoV-2 阳性泪液的最高患病率为 7.5%。然而，与 SARS-CoV-2 相关的眼部结膜炎的最高患病率为 32%。因此，SARS-CoV-2 显然可以感染眼睛，这在 COVID-19 患者的结膜分泌物中得到了证实。
现有数据反映了眼部结构对 SARS-CoV-2 的影响。分析表明，眼部表现是 SARS-CoV-2 的一个指征，特别是结膜炎。此外，没有证据表明眼部结构可以成为 SARS-CoV-2 的另一种传播途径，但仍需要进一步研究。
