Cancer Center, Department of Hematology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, 58 Shangtang Road, Hangzhou, 310014, Zhejiang, China.
Department of Orthopedics, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, 58 Shangtang Road, Hangzhou, 310014, Zhejiang, China.
Clin Transl Oncol. 2023 Jun;25(6):1545-1553. doi: 10.1007/s12094-022-03065-6. Epub 2022 Dec 31.
Acute myeloid leukemia (AML) is an aggressive hematologic cancer in adults. Some patients exhibit restricted T cell infiltration and do not respond to routine treatments. This may be prevented by enhancing adaptive immunity by stimulating innate immune cells inside the tumor microenvironment (TME). To activate the adaptive immunological reaction against tumors, type I interferons (IFNs) can promote the presentation of tumor-specific cytotoxic T lymphocyte (CTL) cell recruitment. During the activation of innate immunity, cyclic di-nucleotides (CDNs) bind to and stimulate the stimulator of interferon genes (STING), a protein localized inside the endoplasmic reticulum (ER) membrane, resulting in the expression of type I IFNs. The efficacy of STING agonists as effective stimulators of the anti-tumor response in AML is being investigated in numerous clinical studies. Therefore, the purpose of this investigation was to thoroughly review existing knowledge in this field and provide perspective into the clinical potential of STING agonists in AML.
急性髓系白血病（AML）是一种侵袭性成人血液系统恶性肿瘤。部分患者表现为 T 细胞浸润受限，对常规治疗无反应。通过刺激肿瘤微环境（TME）内的固有免疫细胞，增强适应性免疫，可能预防这种情况。为了激活针对肿瘤的适应性免疫反应，I 型干扰素（IFN）可促进肿瘤特异性细胞毒性 T 淋巴细胞（CTL）细胞募集的呈递。在固有免疫激活过程中，环二核苷酸（CDNs）与干扰素基因刺激物（STING）结合并刺激其表达，STING 是一种位于内质网（ER）膜内的蛋白，导致 I 型 IFN 的表达。在许多临床研究中，正在研究 STING 激动剂作为 AML 抗肿瘤反应的有效刺激物的疗效。因此，本研究旨在全面综述该领域的现有知识，并探讨 STING 激动剂在 AML 中的临床潜力。
