Barth Bradley B, Spencer Nick J, Grill Warren M
Department of Biomedical Engineering, Duke University, Durham, NC, USA.
College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.
Adv Exp Med Biol. 2022;1383:113-123. doi: 10.1007/978-3-031-05843-1_11.
The characteristic motor patterns of the colon are coordinated by the enteric nervous system (ENS) and involve enterochromaffin (EC) cells, enteric glia, smooth muscle fibers, and interstitial cells. While the fundamental control mechanisms of colonic motor patterns are understood, greater complexity in the circuitry underlying motor patterns has been revealed by recent advances in the field. We review these recent advances and new findings from our laboratories that provide insights into how the ENS coordinates motor patterns in the isolated mouse colon. We contextualize these observations by describing the neuromuscular system underling the colonic motor complex (CMC) as a robust, distributed control system. Framing the colonic motor complex as a control system reveals a new perspective on the coordinated motor patterns in the colon. We test the control system by applying electrical stimulation in the isolated mouse colon to disrupt the coordination and propagation of the colonic motor complex.
结肠的特征性运动模式由肠神经系统（ENS）协调，涉及肠嗜铬（EC）细胞、肠神经胶质细胞、平滑肌纤维和间质细胞。虽然结肠运动模式的基本控制机制已为人所知，但该领域的最新进展揭示了运动模式背后的电路更为复杂。我们回顾了这些最新进展以及我们实验室的新发现，这些发现为ENS如何协调离体小鼠结肠的运动模式提供了见解。我们通过将结肠运动复合体（CMC）的神经肌肉系统描述为一个强大的分布式控制系统，来将这些观察结果置于背景中。将结肠运动复合体视为一个控制系统，为结肠中协调的运动模式揭示了一个新的视角。我们通过在离体小鼠结肠中施加电刺激来破坏结肠运动复合体的协调和传播，从而测试该控制系统。
