Division of Cardiology, Department of Cardiovascular Disease, Peking University First Hospital, Dahongluochang Street, Xicheng District, Beijing, 100034, China.
Echocardiography Core Lab, Institute of Cardiovascular Disease at Peking University First Hospital, Beijing, China.
BMC Cardiovasc Disord. 2022 Dec 31;22(1):579. doi: 10.1186/s12872-022-03004-x.
Left ventricular (LV) geometry is closely associated with cardiovascular disease; however, few studies have evaluated the relationship between basal septal hypertrophy (BSH) and LV geometry. In this study, we examined the relationship between BSH and LV geometry in a Beijing community population.
The clinical and echocardiographic data of 1032 participants from a community in Beijing were analyzed. BSH was defined as a basal interventricular septal thickness ≥ 14 mm and a basal septal thickness/mid-septal thickness ≥ 1.3. On the basis of their echocardiographic characteristics, patients were described as having a normal geometry, concentric remodeling, concentric hypertrophy, or eccentric hypertrophy. Multivariable logistic regression was used to analyze the relationship between BSH, LV mass index (LVMI), and relative wall thickness (RWT).
The prevalence of BSH was 7.4% (95% confidence interval [CI] 5.8-9.0%). Basal and middle interventricular septal thickness, LV posterior wall thickness, and RWT were greater, while LVMI and LV end-diastolic dimension were lower in the BSH group than in the non-BSH group (p < 0.05). The BSH group accounted for the highest proportion of patients with concentric remodeling. A multivariable regression analysis showed that BSH increased by 3.99-times (odds ratio [OR] 3.99, 95% CI 2.05-7.78, p < 0.01) when RWT was > 0.42, but not when LVMI increased (OR 0.16, 95% CI 0.02-1.19, p = 0.07). There were no interactions between BSH and age, body mass index, sex, diabetes mellitus, coronary heart disease, stroke, and smoking in relation to an RWT > 0.42.
BSH was independently associated with an RWT > 0.42.
左心室（LV）几何形状与心血管疾病密切相关；然而，很少有研究评估基底间隔肥厚（BSH）与 LV 几何形状之间的关系。本研究在北京社区人群中研究了 BSH 与 LV 几何形状之间的关系。
分析了来自北京一个社区的 1032 名参与者的临床和超声心动图数据。BSH 定义为基底室间隔厚度≥14mm 和基底间隔厚度/中隔厚度≥1.3。根据他们的超声心动图特征，患者被描述为具有正常几何形状、同心重构、同心肥厚或偏心肥厚。多变量逻辑回归用于分析 BSH、LV 质量指数（LVMI）和相对壁厚度（RWT）之间的关系。
BSH 的患病率为 7.4%（95%置信区间 [CI] 5.8-9.0%）。BSH 组的基底和中层室间隔厚度、LV 后壁厚度和 RWT 较大，而 LVMI 和 LV 舒张末期内径较低（p<0.05）。BSH 组中同心重构的患者比例最高。多变量回归分析显示，当 RWT>0.42 时，BSH 增加 3.99 倍（比值比 [OR] 3.99，95%CI 2.05-7.78，p<0.01），而当 LVMI 增加时则不然（OR 0.16，95%CI 0.02-1.19，p=0.07）。在 RWT>0.42 时，BSH 与年龄、体重指数、性别、糖尿病、冠心病、卒中和吸烟之间没有相互作用。
BSH 与 RWT>0.42 独立相关。
