转座元件与阿尔茨海默病发病机制
Transposable elements and Alzheimer's disease pathogenesis.
作者信息
Evering Teresa H, Marston Jez L, Gan Li, Nixon Douglas F
机构信息
Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY, 10021, USA.
Helen and Robert Appel Alzheimer's Disease Institute, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, 10021, USA.
出版信息
Trends Neurosci. 2023 Mar;46(3):170-172. doi: 10.1016/j.tins.2022.12.003. Epub 2022 Dec 30.
Alzheimer's disease (AD) is characterized by the pathological accumulation of amyloid β (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau. Microglia and astrocytes respond to the abnormal presence of tau protein with induced transposable element (TE) transcription. In this Forum, we discuss new data that link dysregulated TE expression to AD pathogenesis.
阿尔茨海默病（AD）的特征是淀粉样β（Aβ）斑块的病理积累以及由高度磷酸化的tau组成的神经原纤维缠结。小胶质细胞和星形胶质细胞通过诱导转座元件（TE）转录对tau蛋白的异常存在做出反应。在本论坛中，我们讨论了将失调的TE表达与AD发病机制联系起来的新数据。
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