Kim Hyungwoo, Shin Ju-Young, Chen Jing, Kim Ju Hwan, Noh Yunha, Cheong Hee Jin, Oh Yeon-Mok, Guignard Adrienne, Shantakumar Sumitra
GSK, Seoul, South Korea.
School of Pharmacy, Sungkyunkwan University, Seobu-ro 2066, Jangan-gu, Suwon, Gyeonggi-do, 440-746, South Korea.
Infect Dis Ther. 2023 Feb;12(2):545-561. doi: 10.1007/s40121-022-00747-0. Epub 2023 Jan 2.
To better understand the conditions associated with pertussis diagnosis among older adults in South Korea, a matched case-control study was conducted of individuals ≥ 50 years diagnosed with pertussis between 2009 and 2018.
Pertussis cases were identified using the nationwide Health Insurance Review and Assessment service (HIRA) database. Each case was then matched to up to 10 controls identified using the National Health Insurance Service-National Sample Cohort (NHIS-NSC) by age, sex, and geographic region at index date. In the 12 months and 30 days prior to index date, the presence of clinical characteristics previously reported to be related to pertussis and pertussis-like conditions were assessed, respectively. A conditional multivariate logistic regression model was then used to calculate odds ratios (ORs) of pertussis diagnosis, adjusted for each of the characteristics.
Pertussis cases (n = 1004) generally demonstrated a higher prevalence of comorbidities compared to controls (n = 9710). Pre-existing asthma and chronic obstructive pulmonary disease (COPD) within 12 months of index date were associated with a two-fold increased risk of pertussis with adjusted ORs (95% confidence interval) of 2.08 (1.68-2.58) and 2.32 (1.59-3.39), respectively. Gastroesophageal reflux disease [GERD; 2.67 (2.23-3.19)], cancer [1.68 (1.23-2.31)], cardiovascular disease [1.62 (1.31-2.00)], renal disease [1.56 (1.12-2.16)], autoimmune disease [1.50 (1.25-1.79)], and hyperlipidemia [1.43 (1.16-1.77)] were also associated with pertussis diagnosis. Finally, acute respiratory events within 30 days prior to index date, such as pneumonia, acute bronchitis, and upper respiratory tract infection (URTI), were highly associated with increased odds of pertussis diagnosis [adjusted ORs of 8.28 (5.10-13.44), 4.86 (3.84-6.14), and 2.90 (2.30-3.67), respectively].
This study's findings complement and expand upon previous studies on the adult pertussis population, generating real-world data to describe underlying clinical characteristics of those diagnosed with pertussis in South Korea.
为了更好地了解韩国老年人百日咳诊断相关情况，对2009年至2018年间确诊为百日咳的50岁及以上个体进行了一项匹配病例对照研究。
利用全国健康保险审查与评估服务（HIRA）数据库识别百日咳病例。然后根据年龄、性别和索引日期时的地理区域，将每个病例与通过国民健康保险服务 - 全国样本队列（NHIS - NSC）识别出的最多10名对照进行匹配。分别评估索引日期前12个月和30天内先前报告的与百日咳及百日咳样病症相关的临床特征的存在情况。然后使用条件多变量逻辑回归模型计算百日咳诊断的比值比（OR），并针对每个特征进行调整。
与对照组（n = 9710）相比，百日咳病例（n = 1004）的合并症总体患病率更高。索引日期前12个月内已有的哮喘和慢性阻塞性肺疾病（COPD）与百日咳风险增加两倍相关，调整后的OR（95%置信区间）分别为2.08（1.68 - 2.58）和2.32（1.59 - 3.39）。胃食管反流病[GERD；2.67（2.23 - 3.19）]、癌症[1.68（1.23 - 2.31）]、心血管疾病[1.62（1.31 - 2.00）]、肾脏疾病[1.56（1.12 - 2.16）]、自身免疫性疾病[1.50（1.25 - 1.79）]和高脂血症[1.43（1.16 - 1.77）]也与百日咳诊断相关。最后，索引日期前30天内的急性呼吸事件，如肺炎、急性支气管炎和上呼吸道感染（URTI），与百日咳诊断几率增加高度相关[调整后的OR分别为8.28（5.10 - 13.44）、4.86（3.84 - 6.14）和2.90（2.30 - 3.67）]。
本研究结果补充并扩展了先前关于成人百日咳人群的研究，生成了真实世界数据以描述韩国确诊百日咳患者的潜在临床特征。
