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韩国百日咳负担的系统评价。

A systematic review of the burden of pertussis in South Korea.

作者信息

Mungall Bruce A, Kim Hyungwoo, Oh Kyu-Bin

机构信息

Medical Affairs, GSK, Yongsan-gu, Seoul, Republic of Korea.

Medical Affairs, GSK, Singapore.

出版信息

Hum Vaccin Immunother. 2021 Jun 3;17(6):1747-1756. doi: 10.1080/21645515.2020.1844505. Epub 2021 Jan 7.

DOI:10.1080/21645515.2020.1844505
PMID:33412085
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8115764/
Abstract

This review summarizes the published data on epidemiology and burden of pertussis in South Korea as these may be under-categorized. A systematic literature review of PubMed, SCOPUS, EMBASE and KMBASE was performed to identify published literature in South Korea since 2000. Pertussis detection rates among 19 eligible studies range from 0.7% to 100% across different age groups, detection methods and study settings. Highest rates are observed in infants, while adolescents and adults with pertussis infection may suffer from persistent coughing. Vaccination uptake of pertussis booster dose among adolescents and adults remains low while seropositivity (detection of anti-pertussis immunoglobulin G), is high among adults. This review reveals a high burden of vaccine-preventable pertussis in South Korea. Besides primary childhood vaccination, strategies like maternal immunization and decennial revaccination of adults should be considered. Active testing, reporting and better utilization of vaccine registries may provide insights for decision-makers nationwide.

摘要

本综述总结了韩国百日咳的流行病学和疾病负担方面已发表的数据，因为这些数据可能分类不足。我们对PubMed、SCOPUS、EMBASE和KMBASE进行了系统的文献综述，以识别自2000年以来韩国发表的文献。在19项符合条件的研究中，不同年龄组、检测方法和研究环境下的百日咳检出率在0.7%至100%之间。婴儿中的检出率最高，而感染百日咳的青少年和成年人可能会持续咳嗽。青少年和成年人中百日咳加强剂的接种率仍然很低，而成年人中的血清阳性率（抗百日咳免疫球蛋白G的检测）很高。本综述揭示了韩国可通过疫苗预防的百日咳负担较重。除了儿童期的初次疫苗接种外，还应考虑如孕妇免疫和成年人每十年重新接种等策略。积极检测、报告以及更好地利用疫苗登记系统可能为全国的决策者提供参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f39b/8115764/be6c0e5eac2f/KHVI_A_1844505_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f39b/8115764/d35ed93625cc/KHVI_A_1844505_UF0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f39b/8115764/028872347227/KHVI_A_1844505_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f39b/8115764/be6c0e5eac2f/KHVI_A_1844505_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f39b/8115764/d35ed93625cc/KHVI_A_1844505_UF0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f39b/8115764/028872347227/KHVI_A_1844505_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f39b/8115764/be6c0e5eac2f/KHVI_A_1844505_F0002_C.jpg

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Seroprevalence of Pertussis in Healthcare Workers without Adult Pertussis Vaccine Use at a University Hospital in Korea.韩国某大学医院未使用成人百日咳疫苗的医护人员中百日咳血清阳性率。
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