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本文引用的文献

1
Cancer Risk in Congenital Heart Disease-What Is the Evidence?先天性心脏病与癌症风险：有何证据？
Can J Cardiol. 2019 Dec;35(12):1750-1761. doi: 10.1016/j.cjca.2019.09.023. Epub 2019 Oct 9.
2
Congenital heart disease complexity and childhood cancer risk.先天性心脏病的复杂性与儿童癌症风险。
Birth Defects Res. 2018 Oct 16;110(17):1314-1321. doi: 10.1002/bdr2.1390.
3
Identification of LBX2 as a novel causal gene of atrial septal defect.鉴定 LBX2 为房间隔缺损的一个新的致病基因。
Int J Cardiol. 2018 Aug 15;265:188-194. doi: 10.1016/j.ijcard.2018.04.038. Epub 2018 Apr 11.
4
Survival Prospects and Circumstances of Death in Contemporary Adult Congenital Heart Disease Patients Under Follow-Up at a Large Tertiary Centre.当代大型三级医疗中心随访成年先天性心脏病患者的生存前景和死亡情况。
Circulation. 2015 Dec 1;132(22):2118-25. doi: 10.1161/CIRCULATIONAHA.115.017202. Epub 2015 Sep 14.
5
Neural crest cells in cardiovascular development.心血管发育中的神经嵴细胞。
Curr Top Dev Biol. 2015;111:183-200. doi: 10.1016/bs.ctdb.2014.11.006. Epub 2015 Jan 20.
6
Pheochromocytoma and paraganglioma in cyanotic congenital heart disease.青紫型先天性心脏病中的嗜铬细胞瘤和副神经节瘤
J Clin Endocrinol Metab. 2015 Apr;100(4):1325-34. doi: 10.1210/jc.2014-3863. Epub 2015 Jan 12.
7
Morphogenesis and molecular considerations on congenital cardiac septal defects.先天性心脏间隔缺损的形态发生及分子学考量
Ann Med. 2014 Dec;46(8):640-52. doi: 10.3109/07853890.2014.959557. Epub 2014 Oct 13.
8
Cerebellar metastatic papillary thyroid carcinoma in a pediatric patient with complex congenital heart disease.一名患有复杂先天性心脏病的儿科患者出现小脑转移性甲状腺乳头状癌。
J Pediatr Endocrinol Metab. 2012;25(11-12):1195-9. doi: 10.1515/jpem-2012-0162.
9
Neuroblastoma in adolescents: the Italian experience.青少年神经母细胞瘤：意大利的经验
Cancer. 2006 Mar 15;106(6):1409-17. doi: 10.1002/cncr.21751.
10
CYANOTIC MALFORMATIONS OF THE HEART WITH PHEOCHROMOCYTOMA. A REPORT OF FIVE CASES.伴有嗜铬细胞瘤的心脏青紫型畸形。五例报告。
Circulation. 1964 May;29:750-7. doi: 10.1161/01.cir.29.5.750.

先天性心脏病患者的肿瘤发生：神经嵴的可能作用。

Oncogenesis in patients with congenital heart disease: A possible role of the neural crest.

作者信息

Ferrero Paolo, Piazza Isabelle, Giamberti Alessandro, Chessa Massimo

机构信息

ACHD UNIT, Pediatric and Adult Congenital Heart Centre, IRCCS - Policlinico San Donato, San Donato Milanese, Italy.

European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart, ERN GUARD-Heart, Milan, Italy.

出版信息

Ann Pediatr Cardiol. 2022 May-Jun;15(3):273-275. doi: 10.4103/apc.apc_213_21. Epub 2022 Nov 16.

DOI:10.4103/apc.apc_213_21
PMID:36589641
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9802619/
Abstract

Patients with congenital heart disease (CHD) seem to have a higher risk for specific malignancies. We hypothesize a pathogenetic link between particular congenital heart defects and cancer originating from specific cellular lineages. We report a series of patients, followed in two high-volume referral centers, with CHD involving neural crest-derived structures who developed cancer later in life. Fourteen patients (five female) developed neoplasia with a cellular origin embryologically linked to the neural crest between 2010 and 2020. If confirmed on larger datasets, this observation might support the hypothesis of common embryogenetic pathway suggesting tailored surveillance of a specific subset of patients.

摘要

先天性心脏病（CHD）患者似乎患特定恶性肿瘤的风险更高。我们推测特定先天性心脏缺陷与源自特定细胞谱系的癌症之间存在致病联系。我们报告了一系列患者，这些患者在两个大型转诊中心接受随访，他们患有涉及神经嵴衍生结构的先天性心脏病，后来在生命后期患上了癌症。在2010年至2020年期间，14名患者（5名女性）发生了肿瘤，其细胞起源在胚胎学上与神经嵴相关。如果在更大的数据集中得到证实，这一观察结果可能支持共同胚胎发生途径的假设，提示对特定患者亚组进行针对性监测。