中心体蛋白120通过USP54介导的PLK4去泛素化促进中心体扩增和胃癌进展。
Centrosomal protein 120 promotes centrosome amplification and gastric cancer progression via USP54-mediated deubiquitination of PLK4.
作者信息
Zhang Chenggang, Ma Xianxiong, Wei Guanxin, Zhu Xiuxian, Hu Peng, Chen Xiang, Wang Dianshi, Li Yuan, Ruan Tuo, Zhang Weikang, Tao Kaixiong, Wu Chuanqing
机构信息
Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan, Hubei Province 430022, China.
出版信息
iScience. 2022 Dec 7;26(1):105745. doi: 10.1016/j.isci.2022.105745. eCollection 2023 Jan 20.
Centrosomal protein 120 (CEP120) is a 120 kDa centrosome protein that plays an important role in centrosome replication. Overexpression of CEP120 can lead to centrosome duplicate abnormality, which is closely associated with tumorigenesis and development. However, there are no reports on the relationship between CEP120 and tumors. In our study, overexpression of CEP120 promoted centrosome amplification in gastric cancer (GC), and the role of CEP120 in promoting GC progression was demonstrated and . We demonstrated that CEP120 promotes centrosome amplification and GC progression by promoting the expression and centrosome aggregation of the deubiquitinating enzyme USP54, maintaining the stability of PLK4 and reducing its ubiquitination degradation. In conclusion, the CEP120-USP54-PLK4 axis may play an important role in promoting centrosome amplification and GC progression, thus providing a potential therapeutic target for GC.
中心体蛋白120（CEP120）是一种120 kDa的中心体蛋白，在中心体复制中起重要作用。CEP120的过表达可导致中心体复制异常，这与肿瘤的发生发展密切相关。然而，关于CEP120与肿瘤之间关系的报道较少。在我们的研究中，CEP120的过表达促进了胃癌（GC）中的中心体扩增，并证实了CEP120在促进GC进展中的作用。我们证明，CEP120通过促进去泛素化酶USP54的表达和中心体聚集，维持PLK4的稳定性并减少其泛素化降解，从而促进中心体扩增和GC进展。总之，CEP120-USP54-PLK4轴可能在促进中心体扩增和GC进展中起重要作用，从而为GC提供了潜在的治疗靶点。
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